カドミウム汚染地域住民におけるβ2-マイクログロブリンならびにクレアチニンの尿中排泄機序について

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Creatinine clearance (CCr) and relative clearance of β2-microglobulin (β2-m) to CCr (Cβ2-m(%CCr)) were measured among 106 residents, 51 males and 55 females (including 8 patients with, or suspected of having "Itai-itai disease"), aged 13-87 years in a Cadmium (Cd)-polluted area in the Jinzu River basin. The control consisted of 105 residents, 38 males and 67 females, aged 12-84 years in a non-polluted area. Relations of Cβ2-m (% CCr) to the urinary excretion rate of β2-m (μg/min) and the urinary β2-m/creatinine ratio (μg/mg·creatinine) were studied. Residents in a Cd-polluted area aged 50-69 years and over 70 years showed lower CCr and higher Cβ2-m (% CCr) than those of residents in the same age groups in a non-polluted area. CCr showed a tendency to decrease with increasing Cβ2-m(% CCr).Cβ2-m (% CCr) could be predicted by the urinary excretion rate of β2-m. Prediction error was due to interindvidual variations in the product of serum β2-m concentration and CCr, which was considered to depend on the production rate of β2-m. Cβ2-m (% CCr) could also be predicted by the urinary β2-m/creatinine ratio. Prediction error was due to interindividual variations in the serum β2-m/creatinine ratio, which was considered to depend on the ratio of the production rate of β2-m to that of creatinine. However, prediction errors were so small as to be negligible compared with the wide distribution of the urinary β2-m/creatinine ratio (10-2-103μg/mg·creatinine). In most residents of the Cd-polluted area, serum concentrations of β2-m were below the serum threshold value for renal tubular reabsorption (4.0-4.5μg/ml), and raised Cβ2-m (% CCr) could be ascribed to defective renal tubular reabsorption.
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カドミウム汚染地域住民におけるβ2-マイクログロブリンならびにクレアチニンの尿中排泄機序について

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