カドミウム汚染地域住民の腎障害に関する研究 : (第1報)5種類の分子量の異なる血漿由来蛋白の定量にもとづく尿中蛋白排泄パターン分類の試み

スポンサーリンク

概要

• 論文の詳細を見る

• Five urinary proteins were analysed among the 121 inhabitants, 63 males and 58 females aged 2-86 years, of a cadmium polluted area in the Jinzu river basin. The relation between the progression of renal dysfunction and the patterns of protein excretion in urine was studied.1) The urinary excretion of low molecular weight (LMW) proteins larger than β2-microglobulin (β2-m), such as retinol binding protein and α1-microglobulin, increased in proportion to urinary β2-m concentration. When the concentrations of β2-m in urine were over 10mg/g.cr, the excretion of intermediate molecular weight (IMW) proteins, such as albumin (Alb) and Gc-globulin, in urine increased.2) According to the β2-m and Alb concentrations, the urinary protein excretion patterns were classified. Among the inhabitants of the cadmium polluted area, normal type: β2-m under 0.59mg/g.cr and Alb under 40mg/g.cr was 57.9%, LMW protein dominant type: β2-m over 0.59mg/g.cr and Alb under 40mg/g.cr was 26.4%, LMW and IMW protein mixed type: β2-m over 0.59mg/g.cr and Alb over 40mg/g.cr was 15.7% and IMW protein dominant type: β2-m under 0.59mg/g.cr and Alb over 40mg/g.cr was none. The glomerular dysfunction was found by analysis of creatinine clearance and serum creatinine concentrations among inhabitants showing LMW and IMW protein mixed type.3) As age class became higher or residence time in the polluted area became longer, the rates of cases showing LMW protein dominant type or LMW and IMW protein mixed type increased in both sexes in the polluted area. The rates of the cases showing LMW and IMW protein mixed type were higher among females than males. For reference, 47 out of 49 inhabitants of a non polluted area showed normal type and all 34 itai-itai disease patients showed LMW and IMW protein mixed type.The classification mentioned above would be useful and convenient for differentiation of the stages of renal dysfunction caused by cadmium.

• 日本衛生学会の論文

著者

• 窪田 裕子

  富山医科薬科大医公衛

• 窪田 裕子

  富山医薬大 医

関連論文

• 117. ナシ果樹園作業者の花粉症に関する研究 : (I)人工授粉作業時の呼吸機能検査(粉塵・じん肺,一般演題,第57回日本産業衛生学会・第36回日本産業医協議会)
• 11.ナシ果樹園作業者の花粉特異的IgE抗体について(一般講演,第26回北陸甲信越地方会)
• 810 マイクロデンシメトリー法によるイタイイタイ病の骨粗鬆化度の検討(カドミウム,一般講演,第58回日本産業衛生学会・第38回日本産業医協議会)
• 7.ナシ果樹園作業者の花粉症に関する研究II : フィルターマスクの効果について(一般講演,第27回北陸甲信越地方会)
• カドミウム汚染地域住民の腎障害に関する研究 : (第2報)12年の間隔をおいて観察した尿蛋白電気泳動パターンの変化
• カドミウム汚染地域住民の腎障害に関する研究 : (第1報)5種類の分子量の異なる血漿由来蛋白の定量にもとづく尿中蛋白排泄パターン分類の試み
• 1. ナシ果樹園作業者の肺機能について (第25回北陸甲信越地方会)
• カドミウム汚染地域住民におけるβ2-マイクログロブリンならびにクレアチニンの尿中排泄機序について

スポンサーリンク