ウサギ摘出血管に対するカドミウム長時間作用の影響

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The effects of Cadmium (Cd) on the contraction of vascular smooth muscle induced by high potassium (K+) solution and norepinephrine (NE) were investigated in this study. In particular, the effects of low doses of Cd at environmental exposure levels (0.1-10μM) were studied. We used the metheod of tissue culture for exposure of Cd to renal arteries of rabbits for 3 days. Before studying of the effects of 3-day Cd exposure, the contractions of nonincubated arteries and of arteries incubated without Cd were also investigated.The results are as follows:1) The resting tension of non-incubated renal arteries was not affected by 0.1-200μM Cd. However, the contraction induced by K+ or NE was reduced by 100-200μM Cd.2) The contraction sensitivity of renal arteries to NE gradually increased during the incubation period (‘supersensitivity’). These effects were maximal after 3 days of incubation. However, incubation was not affected by contraction induced by K+. Two hundred μM Cd reduced the contractions of incubated arteries induced by K+ or NE.3) The addition of Cd (1-10μM) to the medium inhibited the development of supersensitivity of renal arteries to NE. However, Cd did not affect the contraction of incubated arteries induced by K+.
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