カドミウムのウサギ血圧および腎交感神経発射に及ぼす影響
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The effects of intravenous administration of cadmium (Cd) on arterial blood pressure were investigated in anesthetized, artificially ventilated rabbits. In addition, cadmiums effects on renal sympathetic nerve discharges, ECG, and phrenic nerve efferent discharges were studied to elucidate the mechanisms of blood pressure change. Blood Cd levels were also determined in some animals.<BR>The follwed results were obtained:<BR>1) Intravenous injection of CdCl<SUB>2</SUB> at doses of between 5 and 500μg/kg produced a biphasic fall in blood pressure. The first fall was sharp and transient, and recovered in about 5 minutes (min.). After this, the second fall slowly developed, and returned to the control value 30-60min. after injection. However, at doses of 200-500μg/kg, the first fall was not reversible and lasted for 30-60min.<BR>2) The heart rate was slightly decreased within 30 seconds. after injection. Then it increased during the next 1min., and the increase lasted about 30min.<BR>3) Renal nerve sympathetic discharges increased during the initial rapid fall of blood pressure at doses between 5 and 100μg/kg. These changes were reversible when the blood pressure recovered to normal. However, at higher doses of 200-500μg/kg, renal nerve discharges were reduced during the second blood pressure fall, and did not recover to the control levels.<BR>4) Cd had no discernible effect on the phrenic nerve discharges or end tidal CO<SUB>2</SUB> concentration.<BR>5) The blood concentration of Cd was increased rapidly to the maximal value within about 1min. after injection. Then it decreased rapidly and became stable 30min. after the injection. The blood levels of Cd after doses of 10 and 50μg/kg were 1 and 2μM, respectively.
- 日本衛生学会の論文
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