A Possible Regulatory Role of Ca<SUP>++</SUP>-Calmodulin System in Cellular Cholesterol Ester Hydrolysis in the Steroidogenic Response to ACTH in Bovine Adrenocortical Cells
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概要
- 論文の詳細を見る
order to corroborate the regulatory role of Ca<SUP>++</SUP>-calmodulin system in the steroidogenic response to adrenocorticotropic hormone (ACTH), the effects of calmodulin inhibitors (chlorpromazine, trifluoperazine, and W-7) on cortisol production and cellular cholesterol ester hydrolysis induced by ACTH in bovine adrenocortical cells were examined.<BR>Three calmodulin inhibitors diminished not only the cholesterol ester hydrolysis and cortisol production induced by ACTH in the presence of Ca++, but also inhibited the Ca<SUP>++</SUP>-induced hydrolysis and cortisol production in the absence of ACTH. Neither cortisol production in crude mitochondrial fraction nor the ACTH-induced Ca<SUP>++</SUP>-influx was affected by chlorpromazine.<BR>These results indicate that Ca++-calmodulin system plays a significant regulatory role in the supply of free cholesterol to the adrenal mitochondria in the steroidogenic response to ACTH.
- 社団法人 日本内分泌学会の論文
著者
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MATSUBA MICHIO
Department of Pharmacology, The Jikei University School of Medicine
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Tanaka Yoshiaki
Department Of Gastroenterology Internal Medicine Kitasato University East Hospital
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SEKIMOTO TAKEHITO
Department of Pharmacology, The Jikei University School of Medicine
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NAKAMICHI NOBORU
Department of Pharmacology, The Jikei University School of Medicine
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HANYU JIN
Department of Pharmacology, The Jikei University School of Medicine
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UZAWA SHUNICHI
Department of Pharmacology, The Jikei University School of Medicine
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AMAMOTO TAKASHI
Department of Pharmacology, The Jikei University School of Medicine
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YONEZAWA YOSHIKO
Department of Pharmacology, The Jikei University School of Medicine
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TSURUI MASASHI
Department of Pharmacology, The Jikei University School of Medicine
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ISHIWATARI SEIICHI
Department of Pharmacology, The Jikei University School of Medicine
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IMAGAWA NOBUYUKI
Department of Pharmacology, The Jikei University School of Medicine
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TOMITA CHIYOMI
Department of Pharmacology, The Jikei University School of Medicine
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Tanaka Yoshiaki
Department Bf Physics Faculty Of Science And Engineering Ritsumeikan University
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TANAKA YOSHIAKI
Department of Pharmacology, The Jikei University School of Medicine
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