EFFECTS OF AMINE PRECURSOR ADMINISTRATION ON THE MORPHOLOGICAL FINDINGS OF TRANSPLANTED ARGYROPHIL CELL ADENOCARCINOMA OF THE ENDOMETRIUM

元データ 1982-03-01

概要

子宮内膜銀好性細胞癌をヌードマウスに継代移植し,第4および第6代目移植腫瘍を用いてアミン前駆物質投与による形態学的変化を検討した.子宮内膜銀好性細胞癌はヌードマウスに継代移植されても,形態的にはこれまでに大きな変化は認められていない.銀好性顆粒は移植腫瘍においても原発腫瘍と同じく主として線癌細胞の突端部に認められた.しかし,アミン前駆物質としてのL-DOPA投与後は,銀好性顆粒が細胞質全体に分布している細胞が著明となった.この事実は,子宮内膜銀好性細胞癌には潜在性のAPUD細胞が存在し,投与されたアミン前駆物質を摂取してアミンを産生し,形態的には活性化かれたAPUD細胞として認められることを示唆するものを思われる.

著者

INOUE Masaki Department of Obstetrics and Gynecology, Osaka University Medical School
UEDA Gaiko Department of Obstetrics and Gynecology, Osaka University Medical School
TANAKA Yoshiaki Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
Ueda Gaiko Department Of Obstetrics And Gynecology Osaka University Medical School
Inoue Masaki Department Of Obstetrics And Gynecology Osaka University Medical School
Inoue Masaki Department Of Gynecology And Obstetrics Kanazawa University School Of Medicine
YAMASAKI Masato Departments of Anatomy, Osaka City University Medical School
上田 外幸 Department of Obstetrics and Gynecology, Osaka University Medical School
HIRAMATSU Keizo Department of Obstetrics and Gynecology, Osaka University Medical School
KURACHI Keiichi Department of Obstetrics and Gynecology, Osaka University Medical School
Tanaka Yoshiaki Department Of Obstetrics And Gynecology Osaka University Medical School
Yamasaki Masato Department Of Obstetrics And Gynecology Osaka University Medical School
Yamasaki Masato Department Obstetrics And Gynecology Osaka Rosai Hospital
Ueda Gaiko Department Of Obstetrics And Gynecology Okayama University Medical School
Kurachi Keiichi Department Of Obstetrics And Gynecology Osaka University Medical School
Kurachi Keiichi Department Of Obstetrics & Gynecology Osaka Medical School
INOUE Yoshinosuke Department of Obstetrics and Gynecology, Osaka University Medical School
Hiramatsu Keizo Department Of Obstetrics And Gynecology Osaka University Medical School
Inoue Yoshinosuke Department Of Obstetrics And Gynecology Osaka University Medical School
Inoue Masaki Department Of Architecture And Architectural Engineering Kyoto University
Tanaka Yoshiaki Department Bf Physics Faculty Of Science And Engineering Ritsumeikan University
TANAKA Yoshiaki Department of Obstetrics and Gynecology,Osaka University Medical School
Yamasaki Masato Department of Obstetrics and Gynecology,Osaka University Medical School
KURACHI KEIICHI Department of Gynecology and Obstetrics, Osaka University, Medical School

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