CORRELATIVE LIGHT AND IMMUNOHISTOLOGICAL STUDY OF THE BASEMENT MEMBRANE OF THE HUMAN SQUAMOUS CERVICAL CARCINOMA
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概要
- 論文の詳細を見る
子宮頚部扁平上皮癌に基底膜は存在するか否か光顕・電顕的に多くの研究がなされてきた.1968年Beutner et al.はbullous pemphigioid患者血清が扁平上皮に対する抗基底膜抗体を含むことが明らかにされた.今回,我々は子宮頚部の上皮内癌3例,微小浸潤癌1例,浸潤癌27例を用い,凍結切片を作製し,抗基底膜抗体を含むbullous pemphigioid患者血清を用い蛍光抗体法による基底膜の観察を行なった.更に同一症例について,PAS及びMucin染色を行なった.蛍光抗体法による基底膜の観察では上皮内癌3例及び正常上皮では全て連続した蛍光の線が認められた.浸潤癌27例中7例に陽性で,keratinizing type 1/3, large cell type 6/23, small cell type 1/1例に陽性所見を認めた.CPL分類ではC型3/9,P型5/16,L型0/2が陽性であった.間質細胞反応との関連では細胞浸潤の軽度のもの5/16例,中等度・高度のもの3/11例に陽性であった.PAS及びMucin染色との比較検討を行なうと,PAS陽性基底膜例では3/12に蛍光基底膜が認められた.Mucin染色では浸潤癌1例の管腔に面した細胞の先端に陽性が認められたが残り16例は陰性であった.蛍光基底膜はそれぞれ.1/1,2/16に陽性であった.浸潤癌でも基底膜が健存する例が認められ,浸潤の有無と基底膜の破壊の関係は疑問である.更にPAS染色による基底膜は蛍光抗体法による基底膜と一致しない.
- 社団法人日本産科婦人科学会の論文
- 1980-11-01
著者
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INOUE Masaki
Department of Obstetrics and Gynecology, Osaka University Medical School
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UEDA Gaiko
Department of Obstetrics and Gynecology, Osaka University Medical School
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TANAKA Yoshiaki
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
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Ueda Gaiko
Department Of Obstetrics And Gynecology Osaka University Medical School
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Inoue Masaki
Department Of Obstetrics And Gynecology Osaka University Medical School
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Inoue Masaki
Department Of Gynecology And Obstetrics Kanazawa University School Of Medicine
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YAMASAKI Masato
Departments of Anatomy, Osaka City University Medical School
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Tanaka Yoshiaki
Department Of Obstetrics And Gynecology Osaka University Medical School
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Yamasaki Masato
Department Of Obstetrics And Gynecology Osaka University Medical School
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Yamasaki Masato
Department Obstetrics And Gynecology Osaka Rosai Hospital
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Ueda Gaiko
Department Of Obstetrics And Gynecology Okayama University Medical School
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KURACH IKeiichi
Department of Obstetrics and Gynecology, Osaha University Medical School
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Inoue Masaki
Department Of Architecture And Architectural Engineering Kyoto University
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Tanaka Yoshiaki
Department Bf Physics Faculty Of Science And Engineering Ritsumeikan University
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Kurach Ikeiichi
Department Of Obstetrics And Gynecology Osaha University Medical School
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TANAKA Yoshiaki
Department of Obstetrics and Gynecology,Osaka University Medical School
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Yamasaki Masato
Department of Obstetrics and Gynecology,Osaka University Medical School
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