Effects of a High-Monounsaturated Fat Diet on Glucose and Lipid Metabolisms in Normal and Diabetic Mice
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概要
- 論文の詳細を見る
The beneficial effects of high-monounsaturated fat (high-MUFA) diets on diabetic patients have been reported, whereas studies concerning the effects on animals have been few. Although experiments on animals should be useful in elucidating underlying mechanisms, it is not clear even whether there are benefits of a high-MUFA diet in animals. This study examined the short-term effects of a high-MUFA diet on normal and genetically diabetic mice. The high-MUFA diet supplied 38% of the total calories as fat (26% from MUFA), while a regular diet was 13% fat (3% from MUFA). Normal C57BL/6J and diabetic C57BL/KsJ-db/db mice were fed either the regular or the high-MUFA diet for 1 wk. Serum glucose and lipid levels were then measured. In normal mice, hepatic triglyceride production was also compared between the two dietary groups using the Triton WR1339 method. An oral glucose tolerance test was conducted on the diabetic mice. After 1 wk of feeding to normal mice, the high-MUFA diet was seen to lower serum triglyceride levels and reduce hepatic triglyceride production in comparison with the regular diet; it is suggested that the lowering of triglyceride consists of mechanisms including reduced hepatic triglyceride production. When diabetic mice were fed the high-MUFA diet with a controlled caloric intake, the serum glucose levels lowered without an accompanying deterioration in lipid metabolism and the impaired glucose tolerance was ameliorated. This study demonstrates that a high-MUFA diet can lower serum triglyceride levels in normal mice and improve disorders of glucose metabolism in diabetic mice.
- 日本ビタミン学会の論文
著者
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TANAKA Yoshiaki
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
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TSURU TOMOMITSU
Department of Pediatric Surgery, Kurume University School of Medicine
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MIZOTE HIROYOSHI
Department of Pediatric Surgery, Kurume University Hospital
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Hikida Shigeki
Department Of Pediatric Surgery Kurume University School Of Medicine
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Miyashita A
Central Research Laboratories Ssp Co. Ltd.
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Miyashita Akira
Central Research Laboratories Ssp Co. Ltd.
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UMEHARA Norimitsu
Central Research Laboratories SSP Co., Ltd.
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Umehara N
Central Research Laboratories Ssp Co. Ltd.
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Umehara Norimitsu
Central Research Laboratories Ssp Co. Ltd.
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KOTAKE Jiro
Central Research Labs., SSP Co., Ltd.,
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Kotake Jiro
Central Research Laboratories Ssp Co. Ltd.
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Tanaka Y
Department Of Pediatric Surgery Kurume University School Of Medicine
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Mizote Hiroyoshi
Department Of Pediatric Surgery Kurume University Hospital
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Tanaka Yoshiaki
Global Information And Telecommunication Institute Waseda University:research Institute For Science
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Tsuru Tomomitsu
Department Of Pediatric Surgery Kurume University School Of Medicine
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Tanaka Yoshiaki
Department Of Gastroenterology Internal Medicine Kitasato University East Hospital
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Tanaka Yoshiaki
Global Information And Telecommunication Institute Waseda University:research Institute For Science
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Tanaka Yoshiaki
Department Bf Physics Faculty Of Science And Engineering Ritsumeikan University
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