Extracellular ATP Stimulates Steroidogenesis in Bovine Adrenocortical Fasciculata Cells via P2 Purinoceptors.
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概要
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Effects of ATP and other purine derivatives on steroidogenesis in primary cultured bovine adrenocortical fasciculata cells were examined. At concentrations higher than 1 μM, ATP showed a potent stimulative effect on the cortisol production of the cells. The potency order of the steroidogenic effect of the tested purine derivatives was ATP > ADP >> adenosine >> AMP. α, β-Methylene ATP had no stimulative effect on the steroidogenesis at concentrations as high as 1 mM. Theophylline did not antagonize the steroidogenic effect of ATP. These results suggest that bovine adrenocortical fasciculata cells possess the P<SUB>2</SUB>y purinoceptors that are linked to steroidogenesis.
- 公益社団法人 日本薬理学会の論文
著者
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Niitsu Akiyoshi
Department Of Internal Medicine Jikei University School Of Medicine
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Kawamura Masahiro
Department Of Pharmacology (1) The Jikei University School Of Medicine
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NAKAMICHI NOBORU
Department of Pharmacology, The Jikei University School of Medicine
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MATSUI Takashi
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Ohno Yuji
Department of Electronic Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan
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Kondo Tsutomu
Department of Anesthesiology, The Jikei University School of Medicine
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NAKAMICHI Noboru
Department of Pharmacology I, The Jikei University School of Medicine
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Nakamichi Noboru
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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KAWAMURA Masahiro
Department of Pharmacology I, The Jikei University School of Medicine
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