Procaine inhibits cyclic AMP-induced steroidogenesis in isolated bovine adrenocortical cells.
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概要
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Effects of procaine on dibutyryl adenosine 3', 5'-cyclic monophosphate ((Bu)<SUB>2</SUB>cAMP)-, Ca<SUP>2+</SUP> or forskolin-induced steroidogenesis were examined in isolated bovine adrenocortical cells. Procaine (<1.0 mM) caused a marked suppression of (Bu)<SUB>2</SUB>cAMP or forskolin-induced steroidogenesis in the absence of extracellular Ca<SUP>2+</SUP>, but did not affect on Ca<SUP>2+</SUP>-induced steroidogenesis in the cells. (Bu)<SUB>2</SUB>cAMP decreased the cell associated <SUP>45</SUP>Ca<SUP>2+</SUP>. However, procaine (300 μM) inhibited this effect of (Bu)<SUB>2</SUB>cAMP. These results suggest that procaine may abolish (Bu)<SUB>2</SUB>cAMP-induced Ca<SUP>2+</SUP> release from intracellular calcium store(s) and inhibits steroidogenesis.
- 公益社団法人 日本薬理学会の論文
著者
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Kawamura Masahiro
Department Of Pharmacology (1) The Jikei University School Of Medicine
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Takamura Mitsuyuki
Department Of Epidemiology And Environmental Health Juntendo University Faculty Of Medicine
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YAMADA Kenji
Department of Applied Chemistry, Faculty of Engineering, Chiba University
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TOU Shohei
Department of Pharmacology I, The Jikei University School of Medicine
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NOGUCHI Akibumi
Department of Phamarcology, The Jikei University School of Medicine
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NOGUCHI Akibumi
Department of Pharmacology I, The Jikei University School of Medicine
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YAMADA Kenji
Department of Pharmacology I, The Jikei University School of Medicine
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