Extracellular ATP Potentiates Steroidogenic Effect of Adrenocorticotropic Hormone in Bovine Adrenocortical Fasciculata Cells
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概要
- 論文の詳細を見る
We examined the effect of extracellular adenosine 5-triphosphate (ATP) on adrenocorticotropic hormone (ACTH)- and angiotensin II-induced steroidogenesis in bovine adrenocortical fasciculata cells. The low concentration of ATP (5 μM) potentiated ACTH-induced steroidogenesis synergistically. However, the purine derivative did not affect angiotensin II-induced steroidogenesis. Although adenosine (100 μM) (a metabolite of ATP) showed a weak steroidogenic effect, it did not potentiate ACTH-induced steroidogenesis. ATP also enhanced the steroidogenesis by NaF synergistically in bovine adrenocortical cells, but did not potentiate forskolin-and dibutyryl cyclic AMP-induced steroidogenesis. The stimulating effect of ACTH on cyclic AMP production was synergistically accelerated by ATP (5 μM), which has no effect by itself on cyclic AMP formation. These results suggest that extracellular ATP affected the ACTH receptor-adenylyl cyclase coupling processes, and potentiation of steroidogenesis by ACTH ensued in bovine adrenocortical fasciculata cells.
- 社団法人 日本薬理学会の論文
- 2001-04-01
著者
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KAWAMURA Masahiro
Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Hokkaido University
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MASAKI Eiji
Department of Anesthesiology, Jikei University School of Medicine
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Masaki E
Jikei Univ. School Of Medicine Tokyo Jpn
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Masaki Eiji
Department Of Anesthesiology Jikei University School Of Medicine
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NIITSU Akiyoshi
Department of Internal Medicine, Jikei University School of Medicine
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NISHI Haruhisa
Department of Pharmacology, Jikei University School of Medicine
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Nishi H
Department Of Pharmacology Jikei University School Of Medicine
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Nishi Haruhisa
Department Of Pharmacology (i) Jikei University School Of Medicine
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Niitsu Akiyoshi
Department Of Internal Medicine Jikei University School Of Medicine
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Kawamura M
Jikei Univ. School Of Medicine
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Kawamura Masahiro
Department Of Pharmacology Department Of Internal Medicine Jikei University School Of Medicine
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Kawamura Masahiro
Department Of Pharmacology (1) The Jikei University School Of Medicine
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