コイおよびフナにおける魚類用麻酔剤,3H.2-アミノ-4-フェニールチアゾールの吸収,分布および排泄〔英文〕

概要

論文の詳細を見る
A preliminary survey for the absorption, distribution and excretion of 3H•2-amino-4-phenylthiazole was carried out to determine its anesthetic property, metabolism and residue. To observe the absorption and distribution, the fishes were immersed in fresh water containing 40ppm of 3H•2-amino-4-phenylthiazole hydrobromide for 60min at 12°C. Also to observe the excretion, after immersion for 5 min, the fishes were moved into fresh water and the time course survey was continued for 3hr.A tendency to give rise to a similar absorption or distribution pattern was observed in the hepatopancreas, spleen, kidney, muscle and gonad. Major distribution was, however, found in the brain. The order of distribution in each part of the brain was; medulla oblongata>interbrain ?? midbrain>cerebellum ?? spinal cord>cerebrnm. The critical concentration of this compound in the brain for the initiation of anesthetization was roughly estimated to be 70μg eq./g wet brain.A tendency to give rise to a similar excretion pattern was observed in the blood and brain as a pattern for rapid excretion. In the hepatopancreas, kidney and spleen, after starting of the recovery process, the distribution of this compound was once augmented and then excreted. The major route of absorption or excretion was the gills, while a minor role was played in the bile and urine.
日本水産學會の論文