魚類麻酔剤2-アミノ-4-フェニ-ルチアゾ-ルの残留分析-1-メダカによるラジオトレ-サ-モデル実験〔英文〕

概要

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Residue analyses on 3H•2-amino-4-phenylthiazole were performed in medaka (killifish, Oryzias latipes). This fish was selected because of its ready application in radiotracer experiments and its marked and unique ability to detoxify the piscine anesthetic, 2-amino-4-phenylthiazole to its N-hexuronyl conjugate. The absorption/excretion balance showed an average 102% recovery indicating that the excretion treatment effectively exhausted the residue from medaka. The half-life for retention of this compound and its N-hexuronyl conjugate in the body of the fish was approximately 12-15 hours. The fates of both the anesthetic and its N-hexuronyl conjugate in the fish body were determined separately in a time course survey using TLC radiography. Plots for the excretion of the major product, i. e. the conjugate, and the anesthetic per se produced two crossing exponential curves suggesting that there are two compartmentations of both the conjugate and the anesthetic per se in medaka. A mathematical simulation of the residue was also described.
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