環形動物クチクラコラーゲンの特性 (海産無椎脊動物コラーゲンに関する研究-3,4-〔英文〕)

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Acid soluble cuticle collagens were prepared from some marine worms, Neanthes diversicolor, Marphysa sanguinea, and Lumbriconereis heteropoda, of Polychaeta. These cuticle collagens exhibited a number of anomalous properties as compared with ordinary collagens. The cuticle collagen solution of N. diversicolor behaved as a Non-Newtonian liquid, and showed a strong flow birefringence and a high negative optical rotation characteristic of collagen. The cuticle collagen has been shown to consist of rigid, rod-like particles having a molecular weight of 1, 700, 000, a diameter of 16.2 Å, and a somewhat broad distribution of lengths averaging 9, 000 Å. It denatured at about 29°C and the denatured collagen was composed of two polypeptide chains, one a light component (M. W.: 300, 000) and the other a heavier one (M. W.: 600, 000). The relative ratio of the two components was about 1:1. The alkali treatment at pH 12 converted most of the heavier chain into the light chains. Moreover, the extremely high content of Hyp, the low content of Pro, and the lack of Hyl were found to be characteristic of this cuticle collagen. Other two cuticle. collagens were found to have similar chemical composition and physical properties. From these results, a possible structure for these unusual collagens was suggested.
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