Hanganutziu-Deicher(H-D) antigen and antibody in liver disease.

概要

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Hanganutziu-Deicher (H-D) antibody activities in the sera of patients with various liver diseases were examined by the enzyme immunoassay (EIA) using high molecular weight glycoprotein (HMWGP) as H-D antigen.<BR>Mean O.D. values of IgG class H-D antibodies were significantly high in CH, LC and HCC patients as compared with normal individuals. On the other hand, the mean O.D. values of IgM class H-D antibodies was significantly high in LC patients alone. The positive percent of IgG class H-D antibodies was 5.7% in AH, 28.1% in CH, 21.9% in LC and 26.9% in HCC, increasing as the illness progressed. There was no difference in the incidence of positive IgM class H-D antibody among the liver diseases studied.<BR>H-D antibody activities in patients with chronic liver diseases did not change during their clinical courses, whereas those of patients with AH decreased with improvement of their illness, and out of seven HCC patients subjected to transcatheter arterial embolization, the H-D antibody activities increase greatly in two. H-D antigens were not detected in liver disease sera, but these results suggest that infection with hepatitis virus or necrosis of hepatic cells might stimulate the formation of H-D antibodies.