Protective effect of dibutyryl adenosine 3',5'-monophosphate on chronic liver damage induced by carbon tetrachloride in the rat.

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An effect of dibutyryl adenosine 3'-5'-monophosphate (DBcAMP) on chronic liver injury induced by carbon tetrachloride (CCl4) was investigated. Fifty male Wistar rats were divided into the following groups: (1) controls (n=20), treated with CCl4 only; (2) rats treated with DBcAMP simultaneously with CCl4 (n=30). CCl4 (0.2ml/100g bw) was injected subcutaneously twice weekly, and DBcAMP (1.0 mg/100g bw)was administered intraperitoneally twice daily and six days weekly. All animals receiving CCl4 alone showed parenchymal cell damage and hepatic fibrosis within a short period of time, which led to liver cirrhosis and died of hepatic failure within 15 weeks of treatment. Microangiograms represented conspicuous rarefaction of the intrahepatic vascular beds and disordered vascular contour, Animals treated with DBcAMP, on the other hand, showed neither rarefaction of the vascular beds nor atrophy of the liver and all animals survived even consecutive CCl4 exposure for 17 weeks. It is concluded that in protecting microcirculatory system of the liver, DBc-AMP provides potent preventive effect on the chronicity of liver damage induced by CCl4.
社団法人日本肝臓学会の論文