Intrahepatic microvascular changes in the malignant transformation of macronodular cirrhosis in rats.

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It is now generally accepted that macronodular cirrhosis is most frequently associated with hepato-cellular carcinoma (HCC). In this study, the mode of changes in the intranodular microvasculature was investigated during the course of malignant transformation in macronodular cirrhotic rat induced by 3'-Me-DAB feeding (for 5 weeks on diet containing 0.06%) plus carbon tetrachloride (CCL4) injection (subcutaneously of 0.2ml/100g bw twice weekly for 14 consecutive weeks). The nodules increased in size with time. Microangiograms of the enlarged nodules showed hypovascularity, which led to adenoma formation by the 7th week after cessation of CCl4 injection. The second CCl4 administration, which was started at the 11th week after cessation of the first exposure, produced neovascularity in the nodules, where HCC was disclosed histologically. It is cancluded that macronodular cirrhosis is a precancerous lesion and the intranodular microcirculatory derangement is highly responsible for the malignant transformation.
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