Microangiographical studies on familial polyosis coli.

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The characterristics of vascular structure in the adenoma of familial polyposis coli were studied with microangiographic technique. Materials were obtained from 4 patients with familial polyposis coli by surgery (n=3) and necropsy (n=1) including 928 lesions of adenoma and 27 lesions of carcinoma in adenoma. The vascular structure was examined by stereomicroscopic, roentgenographic and histopathologic procedures. Results were as follows : 1) The vascular structure of adenoma was classified into three basic types which were palisading type, fan-like radiating type and tree-branching type. 2) The frequency of each type was 16 %, 57 % and 27 % respectively. The frequency of the tree-like branching type was twice as much as control polyps of non-polysis patients and relative to prognosis. 3) The tree-like branching type was also seen in the small adenoma less than 5 mm in size, but was not seen in the adenomas of non-polyposis patients. 4) The vascular structure in the adenomatous portion of the carcinoma in adenoma was mainly (74 %) the tree-like branching type. <BR>We concluded that the familial polyposis coli is characterized by the presence of a large number of polyps with blood vessels showing the tree-like branching pattern suggesting highly malignant potentiality even during stages of early small adenomas compared with the control group.
日本大腸肛門病学会の論文