経口腸管洗浄液の安定性および細菌汚染に関する検討

概要

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The modified Brown's method has been commonly used when preparing the colon for colonoscopy or colonic surgery. Recently, however, a new faster and simpler method, using orally administrable gastrointestinal lavage solution composed of polyethylene glycol 4000 and 4 types of electrolytes, has become recognized. This preparation has been already in market in U.S. A., under the name of Golytely ^<TM>, though not available in Japan. We prepared the solution at our hospital, it is known as CCS (colon clean solution) for clinical use. Due to the limited information available about the stability and bacteriological features of the pharmaceutical preparation, we attempted to corroborate it. Results showed that contents were stable for 8 weeks, but bacteriologically not stable without aseptic preparation. Therefore, it is recommended that storage should be limited to within 1 week at 5℃ in general preparation.
日本医療薬学会の論文