Long-term follow up study of anti-HBs response to human plasma derived hepatitis B vaccine and its prophylactic effect.

概要

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In order to clarify the prophylactic effects of HB vaccine to HBV contamination and the duration of antibody response, 200 subjects who had received HB vaccine were followed up for 47 months. The following results were obtained. 1) Anti-HBs response was noted in 55 of 59 (93.2%) male recipients and 117 of 121 (96.7%) female recipients by PHA or RIA. 2) Mean anti-HBs titers (PHA) reached a peak at 11 months in male recipients and 6 months in females, with titers (2<SUP>N</SUP>) of 6.4 and 8.0, respectively. 3) Sharp rise of anti-HBs titer within one month was noted in the recipients possesing low titer anti-HBs only detected by RIA. 4) Revaccination was undertaken 46 months after the first innoculation in six subjects. One month later, all six subjects showed anti-HBs titers higher than 25 by PHA, suggesting a booster effect following the revaccination.
社団法人日本肝臓学会の論文