A case of primary biliary cirrhosis with positive anti-M8 and with high levels of serum transaminases.

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A case of primary biliary cirrhosis (PBC) with high levels of serum transaminases like viral hepatitis is reported. The patient was a 37-year-old woman. Her liver function showed higher levels and larger changes of serum transaminases compared with serum biliary enzymes. Anti-mitochondrial antibody (AMA) was positive (160×). Histology of liver biopsy showed the findings of chronic nonsuppurative destructive cholangitis (CNSDC), but showed no piecemeal necrosis. The subtypes of AMA were anti-M2 and anti-M8, but not anti-M4. Though this case showed changes of serum transaminases like chronic active hepatitis (CAH), it was not CAH-PBC mixed type because of negative anti-M4 and no piecemeal necrosis. High levels of serum transaminases of this case seemed to be related to positive anti-M8. The clinical course of this case should be carefully followed.
社団法人日本肝臓学会の論文