実験喘息における気管組織抗体の証明法に関する研究 : われわれの一新法を含めて

概要

論文の詳細を見る
It has been well known that the trachea and the bronchus have not only analogous histologic structures, but also similar responses to bronchospastic and bronchodilator drugs. On this ground, we attempted to clarify with isolated trachea from sensitized guinea pig whether bronchial contraction is caused by allergic reaction in the experimental asthma. Three methods, tracheal chain and tracheal spiral, both of which have already been reported, and our new method, were used in this study. Our method was so designed that the surface of solution in a fine glass tube, connected to isolated trachea, might be moved by tracheal contraction and dilatation, in order to be recorded. From result of comparative study on these three methods, we found that tracheal responses to several drugs were more sensitive in tracheal spiral and our method than in tracheal chain. By use of these better two methods, we could demonstrate that trachea was contracted specifically by addition of antigen in the same way as the ileum in the Schulz-Dale method. Since the contraction elicited by the antigen in the sensitized trachea is initiated by reaction of antibody with antigen, this fact proves that specific tissue antibody exists also on the trachea as on the ileum removed from sensitized guinea pig, suggesting that bronchial contraction based on allergic reaction plays a role in the experimental allergic asthma.
日本アレルギー学会の論文
1962-02-28