原発性胆汁性肝硬変の胆管病変に関する病理組織学的研究-肉芽腫の存在意義に関する光顕的研究-
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Primary biliary cirrhosis (PBC) is histologically characterized by chronic non-suppurative destructive cholangitis (CNSDC), and is also a granulomatous disease. The characteristics of granulomas and the correlation between granulomas and bile duct changes were morphologically investigated.<BR>Results were as follows:<BR>1. Most of the granulomas were poorly-defined, and well-organized granulomas with multinucleated giant cells and fibrosis were rare.<BR>2. All granulomas were found in portal area. Some of them were in contact with damaged bile ducts.<BR>3. PBC patients with granulomas were rather early in the histologic stages. Of these 9 patients, four were asymptomatic.<BR>4. Ratio of disappearance of interlobular bile ducts was significantly lower in PBC patients with granulomas than those without granulomas.<BR>From these results, it was suggested that granulomas in PBC were closely related to interlobular bile duct lesions and that something derived from interlobular bile ducts seemed to play an important role for granuloma formation.
- 社団法人 日本肝臓学会の論文
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