肝特異抗原に関する研究--肝特異抗原の肝細胞膜局在

概要

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The anti-serum against rat liver plasma membrane was raised by immunization of rabbits with isolated rat liver plasma membrane. Absorption of the serum by the particulate fractions of rat kidney and lung homogenate produced that which reacted only with liver homogenate, suggesting that liver specific antigen was a component of liver plasma membrane. By this liver-specific antiserum, two different antigens were identified in the liver plasma membrane. One of them was released from the membrane by the treatment by NaCl and EDTA. This salt-soluble antigen was found in the cytoplasmic fraction of liver homogenate as well. The other was solubilized by the treatment with Triton X-100, not by the salt treatment. The former salt-soluble antigen was found to be species non-specific.
社団法人日本肝臓学会の論文