2姉妹のHBs抗原キャリア-に重感染したA型肝炎

概要

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During the course of an epidemic outbreak of hepatitis A in Noboribetsu Onsencho, Hokkaido, two sibling cases with hepatitis A were found to be of dual infection superimposed upon the HBs-antigen carrier state. During the clinical courses of these two cases, both both HBs-antigen titers and HBc-antibody titers were found to undergo characteristic fluctuations. In Case No. 1, both HBs-antigen titer and HBc-antibody titer showed temporary declines in the convalescence stage of hepatitis A, followed by recoveries and subsequent stabilization of the titers. In Case No. 2, the HBc-antibody titer similarly showed a temporary decline in the convalescence, followed by a similar recovery and subsequent stabilization.<BR>In view of the limited literatures on HAV infection superimposed upon the HBs-antigen carrier state, the significance of the present observation was discussed, with comments on the available literatures.
社団法人日本肝臓学会の論文