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The occurrence of glycoprotein antigens (M1, M2 and M3) was investigated in tissues of colonic adenoma and colonic adenocarcinoma by immunoperoxidase methods as compared with that in human fetal colonic mucosa.M3 was detected in all cases with colonic adenoma, and in 30% of them, M1 was also detected. In approximately 60% of cases with colonic adenocarcinoma, M3 was detected and, in addition, M1 was simultaneously detected in 22% of the M3-positive cases. However, none of antigens were detected in the remaining cases. In the mucosa adjacent to colonic adenocarcinoma, M1 which was never detected in normal colonic mucosa was observed. Both M3 and M1 were simultaneously detected in the colonic mucosa in a middle stage of fetal gestation. In a late stage followed by differentiation and maturation of the colonic mucosa, M3 became the main antigen, since M1 gradually disappeared.From these results, these glycoprotein antigens seem to be of a significance as differentiated antigens in human gastrointestinal mucosa.
財団法人日本消化器病学会の論文