Smoking and Colorectal Cancer in a Non-Western Population: a Prospective Cohort Study in Japan
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概要
- 論文の詳細を見る
The risk of colorectal cancer in relation to smoking habits has been examined mostly in Caucasians, and evidence for other ethnic groups is still scarce. METHODS: Our data came from the Japan Collaborative Cohort (JACC) Study. From 1988 through 1990, 25, 260 men and 34, 619 women aged 40-79 years completed a questionnaire on cigarette smoking and other lifestyle factors. Hazard ratios (HR) were estimated by fitting proportional hazards models. RESULTS: During the mean follow-up of 7.6 years through December 1997, we documented 408 incident colon cancers and 204 rectal cancers. We found a non-significant increase in colon cancer risk in male current smokers compared with never smokers. The multivariate-adjusted hazard ratios were 1.07 (95% confidence interval [CI]: 0.72-1.59) for ex-smokers and 1.23 (95% Cl: 0.85-1.78) for current smokers. We however failed to observe a clear dose-response relationship between smoking intensity or duration and colon cancer risk. The adjusted hazard ratio was 1.07 (95% Cl: 0.71-1.61) even for 40+ years of smoking. Almost no increase in colon cancer risk was detected for female smokers, and male smokers were not at an enhanced risk of rectal cancer. CONCLUSIONS: Cigarette smoking was not a strong risk factor for colorectal cancer even after a long-term exposure, although a weak association remains open to discussion. J Epidemiol 2003;13:323-332.
- 日本疫学会の論文
著者
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WAKAI Kenji
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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Toyoshima Hideaki
Department Of Medical Cardiology National Cardiovascular Center
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Tokudome Shinkan
Department Of Community Health Scinece Saga Medical School
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Wakai Kenji
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institution
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Kojima Masayo
Department Of Biosciences Teikyo University Of Science & Technology
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Watanabe Yoshiyuki
Department Of Biotechnology And Chemistry School Of Engineering Kinki University
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Hashimoto Shuji
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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Suzuki Koji
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Ito Yoshinori
Department Of Biochemistry Nagoya City University Medical School
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Tamakoshi Koji
Department Of Nursing Nagoya University School Of Health Sciences
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Hayakawa Norihiko
Department Of Epidemiology And Social Medicine Research Institute For Nuclear Medicine And Biology H
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Hayakawa Norihiko
Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University
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Tamakoshi Kiko
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School ofMedicine
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Toyoshima Hideaki
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine
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SUZUKI Koji
Department of Agricultural Chemistry, University of the Ryukyus
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