Elevated Serum Fructosamine Concentration as an Index of Risk State of Abnormal Glucose Metabolism for Coronary Atherosclerosis

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To examine the usefulness of hyperfructosaminemia as an index of risk state of abnormal glucose metabolism for coronary atheroscrelotic disease, serum fructosamine concentration was compared between 130 male cases with coronary stenosis, aged 60 years or younger, and 260 age-matched male controls. Past history of diabetes mellitus (DM) and information on confounders such as serum lipid concentration, obesity, smoking habits, and family history of ischemic heart disease were obtained from all the subjects. There was no difference in frequency of the past history of DM between the cases (8.5%) and the controls (6.9%), but that of hyperfructosaminemia (cases : 36.2%, controls : 15.0%) was significantly higher in the cases than in the controls (p<0.01). When confounding effects by other risk factors were adjusted by multiple logistic regression analysis, the odds ratio of the past history of DM (1.19, 95% confidence interval : 0.47˜3.03) was not significant, but that of hyperfructosaminemia (3.59, 95% confidence interval : 1.94˜6.65) was significant after the past history of DM was replaced by it. Thus, abnormal glucose metabolism evaluated by hyperfructosaminemia was an independent coronary risk factor, although that evaluated by the past history of DM was not. These results suggest that serum fructosamine is a useful index of coronary risk state related to abnormal glucose metabolism. J Epidemiol, 1992; 2 : 105-110.
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