Birth Weight and Adult Hypertension : Cross-Sectional Study in a Japanese Workplace Population
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概要
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Background Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. Methods and Results A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure ≧140 mmHg and/or diastolic blood pressure ≧90mmHg and/or under treatment by antihypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500g, 2,500-<3,000g, 3,000-<3,500g, 3,500-g, respectively (p-value for trend=0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. Conclusion Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.
- 社団法人日本循環器学会の論文
- 2006-02-20
著者
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大和 浩
産業医科大学産業生態科学研究所健康開発科学
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YATSUYA Hiroshi
Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in He
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KONDO Takaaki
Department of Medical Technology, Nagoya University School of Health Sciences
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TOYOSHIMA Hideaki
Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in He
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Kondo Takaaki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Wakai K
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Wakai Kenji
愛知県がんセンター研究所 疫学予防部
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TAMAKOSHI Koji
Department of Public Health/ Health Information Dynamics, Program in Health and Community Medicine,
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Matsushita Kunihiro
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Toyoshima Hideaki
Department Of Medical Cardiology National Cardiovascular Center
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Toyoshima Hideaki
愛知教育大学
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Miyanishi K
Department Of Public Health-health Information Dynamics Field Of Social Life Science Nagoya Universi
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Matsushita Kunihiro
Departments Of Cardiology Chubu Rosai Hospital
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Mitsuhashi Hirotsugu
Department of Cardiology, Nagoya University Graduate School of Medicine
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OTSUKA Rei
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medici
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HOTTA Yo
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medici
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Ouyang Pei
Department Of Public Health-health Information Dynamics Field Of Social Life Science Nagoya Universi
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Otsuka Rei
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Otsuka Rei
Department Of Epidemiology National Institute For Longevity Sciences National Center For Geriatrics
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Wada Keiko
Department Of Public Health Kobe University Graduate School Of Medicine
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Sugiura Kaichiro
Department of Cardiology, Kami-iida Daiichi General Hospital
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Mitsuhashi Hirotsugu
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Sugiura Kaichiro
Departments Of Public Health Health Information Dynamics:cardiology Nagoya University Graduate Schoo
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Sugiura Kaichiro
Department Of Cardiology Kami-iida Daiichi General Hospital
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Yatsuya Hiroshi
Department Of Pubic Health Nagoya University School Of Medicine
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Hotta Yo
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Matsushita Kunihiro
Department Of Cardiology Nagoya Daini Red Cross Hospital
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Yang Pei
Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medici
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Mitsuhashi Hirotsugu
Department Of Cardiology Nagoya Graduate School Of Medicine
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Hori Yoko
Program In Nursing Nagoya University Graduate School Of Medicine
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Takei Hiroyuki
Second Department Of Surgery
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Takei Hiroyuki
Division Of Breast Surgery Saitama Cancer Center
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Hori Yoko
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Kato Masataka
Department Of Cardiology Chubu-rosai Hospital
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Hotta Yo
Department Of Public Health/health Information Dynamics Nagoya University Graduate School Of Medicin
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Wakai Kenji
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Matsushita Kunihiro
Department Of Cardiology Chubu-rosai Hospital
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Tamakoshi Koji
Department Of Nursing Nagoya University School Of Health Sciences
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Wada Keiko
Department Of Epidemiology & Preventive Medicine Gifu University Graduate School Of Medicine
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