:Report of a Case

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Metronidazole was given to five cases of Crohn's disease. The group consisted of two males and three females (age range 20-37 year. median age 24.6 year). Three patients had ileal and colonic involvement and two patients had only colonic involvement. A favorable response was obtained in two cases. One was a 21-year-old man with colonic involvement, who received daily doses of 0.5g of metronidazole for 137 days. The other one was a 20-year-old man with ileal and colonic involvement, but main lesion was in colon. With the dose of 1.0g daily, for 89 days, paresthesia of lower extremities developed in the second case and the drug was withdrawn despite of a favorable response for Crohn's disease. One of three non-responders showed abdominal pain as an adverse reaction.<BR>We recommend the metronidazole for the treatment of Crohn's disease in which the colon is involved such as Crohn's colitis and Crohn's enterocolitis.
日本大腸肛門病学会の論文