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There are only a few reports on the result of treatment for severe ulcerative colitis in Japan. Our nine cases with severe ulcerative colitis were reviewed. Most of them were given 40mg of prednisolone (p.o) per day in vain and the dosage was increased to 60mg/day. Finally four cases got remission and five cases had surgery. Latest collected cases by National Survey, in which severe cases were treated with a combination of steroid hormone and ED or IVH, showed a poorer remission rate than ours. <BR>Prednisolone of 40mg (p.o) per day employed in our series recommended by the National Study Group for Ulcerative Colitis was not sufficient in dosis for severe ulcerative colitis. Therefore, we recommend an intensive intraveous regimen reported by Truelove et al.. It shows a high remission rate and defines criteria clearly for a surgical intervention.
日本大腸肛門病学会の論文