Distribution and Responses of the Cardiac Sympathetic Receptors to Mechanically Induced Circulatory Changes

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Distribution and mode of excitation of the cardiac sympathetic receptors following mechanically induced circulatory changes were examined in dogs anesthetized with pentobarbital sodium under artificial respiration and the following results were obtained:The receptors, from which the afferent impulses originated and traveled in the left upper thoracic white rami, were distributed on the surface of the left ventricle, left atrium, left coronary artery, ascending and descending thoracic aortae, main pulmonary artery, left pulmonary veins, pericardium, pleura of left side and in some cases on the surface of the right ventricle near the anterior descending artery. On the other hand, the afferent impulses recorded from the right upper thoracic white rami were from the right ventricle, right atrium, main pulmonary artery, right pulmonary veins, right side of aortic root, superior and inferior caval veins, pericardium, pleura of right side and in some cases from the surface of the left ventricle near the anterior descending artery.The afferent impulses from the left ventricle appeared spontaneously at each ascent or in some cases, on the contrary, at each descent of the left ventricular tension or pressure. The impulses increased with post-extrasystolic potentiation of the left ventricular contraction. Also, they increased with an increase in left ventricular contraction produced by occluding the aorta. On the other hand, carotid sinus stimulation resulted in a decrease in number of the impulses per beat. The impulses increased during occlusion of the anterior descending branch of the left coronary artery with or without tugging. Also, they increased markedly following coronary embolism.It was concluded from these findings that the afferent sympathetic fibers originated from the receptors in the left or right ventricle traveled respectively in the left or right upper thoracic white rami and that the cardiac receptors which are considered to participate in pain sensibility were activated by mechanically induced circulatory alterations.
International Heart Journal刊行会の論文

Distribution and Responses of the Cardiac Sympathetic Receptors to Mechanically Induced Circulatory Changes

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