NON-UNIFORM BLOOD FLOW THROUGH THE ISCHEMIC MYOCARDIUM INDUCED BY STELLATE GANGLION STIMULATION

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The effect of electrical stimulation of the stellate ganglion on the blood flow through the ischemic myocardium was examined in anesthetized open-chest dogs. The flow was continuously monitored by heated cross-thermocouples. The anterior descending branch of the left coronary artery was constricted in order to produce various ischemic states in the anterior wall of the left ventricle. Following stimulation, the flow through the outer half of the wall was increased before constriction, was slightly reduced during mild constriction, was markedly reduced during moderate constriction and was slightly reduced or increased during severe constriction. The flow through the inner half was not infrequently reduced before constriction, was slightly reduced or increas-ed during mild constriction and was markedly increased during moderate or severe constriction. These flow changes had a relation to the pressure gradients between the constricted and non-constricted branch. The flow through the zones adjacent to the constricted area was augmented by stimulation. Pretreatment with propranolol eliminated these flow changes. These results suggest the regional difference of sympathetic regulation of the myocardial blood flow and the dependence of its modality on the severity of ischemia. It is supposed that stimulation-induced reduction in the flow through the moderately ischemic myocardium was due to 'coronary steal' and that its occurrance is dependent on the severity of constriction of the coronary artery.
社団法人日本循環器学会の論文
1972-09-20

NON-UNIFORM BLOOD FLOW THROUGH THE ISCHEMIC MYOCARDIUM INDUCED BY STELLATE GANGLION STIMULATION

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