Responses of Renal Mechanoreceptors to Vasopressor Substances

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Responses of the renal mechanoreceptors to vasopressor agents were examined in mongrel dogs anesthetized with pentobarbital sodium. On injecting the agents, intrarenal pressure fell at first, then returned gradually to control level and overshot thereafter. Renal venous pressure, however, was not always changed in parallel with intrarenal pressure. The frequency of the impulses of low voltage, spontaneously discharging and slowly adapting units increased transiently at the onset of the fall in the intrarenal pressure, then decreased or disappeared. Thereafter, the frequency increased markedly with the return or overshooting of the pressure. The impulses of higher voltage and threshold, not spontaneously discharging and rapidly adapting units appeared transiently at the fall or return of the pressure. These findings are similar to those obtained in the previous studies in which the intrarenal pressure was altered mechanically to different direction from either renal arterial or venous pressure.It is concluded that the mechanoreceptors were excited by the vasopressor agents indirectly through the alterations in the intrarenal pressure.
International Heart Journal刊行会の論文