Studies on Prediction of Hypertension in Spontaneously Hypertensive Rats (SHR):(2) Water-induced Exaggerated Natriuresis
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概要
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Urinary Na excretion following acute peroral water loading was clearly increased in SHRSP and SHR compared with WKY even at the age of 4 weeks before the development of hypertension. Cold exposure before and after adrenal denervation did not affect such water-induced exaggerated natriuresis which, therefore, might possibly be involved in genetic mechanism or disposition to hypertension. Since these hypertensive models are prone to retain Na intracellularly (Yamori: In "Hypertension; Physiopathology and Treatment": 556-581, 1983), acute water loading may enhance urinary Na excretion. This phenomenon observed even in prehypertensive stage can be utilized as a predictor for hypertension in SHR and SHRSP and possibly for essential hypertension in men.
- International Heart Journal刊行会の論文
著者
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NARA Yasuo
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases
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Ikeda Katsumi
WHO Collaboratina Center
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Yamori Yukio
Who Collaborating Center
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Mano Masayuki
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Japan Stroke Prevention Center and Shimane Medical University
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Horie Ryoichi
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases and Department of Pathology, Shimane Medical University
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Kihara Masahiro
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Japan Stroke Prevention Center and Shimane Medical University
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Horie Ryoichi
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Japan Stroke Prevention Center and Shimane Medical University
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Ikeda Katsumi
WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases, Japan Stroke Prevention Center and Shimane Medical University
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