Pharmacokinetics of Penciclovir after Oral Administration of Its Prodrug Famciclovir to Horses
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概要
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We investigated the pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses. Following an oral dose of famciclovir at 20 mg/kg, maximum plasma concentrations of penciclovir occurred between 0.75 and 1.5 hr (mean 0.94 ± 0.38 hr) after dosing and were in the range 2.22 to 3.56 μg/ml (mean 2.87 ± 0.61 μg/ml). The concentrations of penciclovir declined in a biphasic manner after the peak concentration was attained. The mean half-life of the rapid elimination phase was 1.73 ± 0.34 hr whereas that of the slow elimination phase was 34.34 ± 13.93 hr. These pharmacokinetic profiles observed were similar to those of another antiherpesvirus drug, acyclovir, previously reported in horses following oral dosing of its prodrug valacyclovir.
著者
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NAGATA Shun-ichi
Laboratory of Racing Chemistry
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KUROSAWA Masahiko
Laboratory of Racing Chemistry
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Tsujimura Koji
Epizootic Research Center Equine Research Institute The Japan Racing Association
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Yamada Masayuki
Laboratory Of Racing Chemistry
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Matsumura Tomio
Epizootic Research Center Equine Research Institute Jra
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Yamanaka Takashi
Epizootic Research Center Equine Research Institute Japan Racing Association
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Kondo Takashi
Epizootic Research Center Equine Research Institute Japan Racing Association
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Nemoto Manabu
Epizootic Research Center Eri Jra
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