Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan
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概要
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A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 Gsub2254/sub) in the Hidaka district-a major horse breeding area in Japan-we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 Gsub2254/sub strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%).br
著者
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MURANAKA Masanori
Epizootic Research Center, Equine Research Institute, Japan Racing Association
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Katayama Yoshinari
Epizootic Res. Station Equine Res. Inst. Japan Racing Assoc.
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Tsujimura Koji
Epizootic Research Center Equine Research Institute The Japan Racing Association
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Matsumura Tomio
Epizootic Research Center Equine Research Institute Jra
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Yamanaka Takashi
Epizootic Research Center Equine Research Institute Japan Racing Association
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Kondo Takashi
Epizootic Research Center Equine Research Institute Japan Racing Association
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Muranaka Masanori
Epizootic Research Center Equine Research Institute The Japan Racing Association
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Bannai Hiroshi
Epizootic Research Center Eri Jra
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Nemoto Manabu
Epizootic Research Center Eri Jra
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OYAMA Takeshi
Hokkaido Hidaka Livestock Hygiene Service Center
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KATO Masakatsu
Hokkaido Hidaka Livestock Hygiene Service Center
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