Two Cases of Refractory Wegeners Granulomatosis Successfully Treated with Rituximab
スポンサーリンク
概要
- 論文の詳細を見る
Conventional therapy for Wegeners granulomatosis, steroid and cyclophosphamide, fails to control disease activity in some refractory patients and has treatment-related toxicity. B cell depletion therapy using rituximab, a chimeric anti-CD20 monoclonal antibody, has been shown to be effective for certain autoimmune diseases including antineutrophil cytoplasmic antibody (ANCA) -associated systemic vasculitis. We report two refractory cases of Wegeners granulomatosis: one with bronchial and pulmonary involvement and retroorbital granuloma, the other with retroorbital granuloma and hypertrophic pachymeningitis causing severe headache. Rituximab was effective in both cases, with diminished granuloma and reduced ANCA titers, allowing steroids to be tapered. No adverse effects were detected.
- 社団法人 日本内科学会の論文
著者
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Morimoto Shinji
Department of Cardiology, Komatsushima Red Cross Hospital
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Ikeda Makoto
Department Of Agricultural Chemistry Tohoku University:(present)section Of Phytochemical Research Ei
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Matsudaira Ran
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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TAJIMA Michiko
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
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Tajima Michiko
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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Hashimoto Hiroshi
Department Of Adult Disease Jr Tokyo General Hospital
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Nawata Masuyuki
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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Kaneda Kazuhiko
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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Tamura Naoto
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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Kobayashi Shigeto
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
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HIRASHIMA Mika
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
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Takasaki Yoshinari
Department of Internal Medicine and Rheumatology
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Takasaki Yoshinari
Department of Internal Medicine
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Hashimoto Hiroshi
Department of Internal Medicine, Juntendo Koshigaya Hospital
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