Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine
スポンサーリンク
概要
- 論文の詳細を見る
The efficacy of two antimicrobial preservatives, 2-phenoxyethanol (2-PE) and Thimerosal, was compared in adsorbed diphtheria-purified pertussis-tetanus combined vaccine (DPT vaccine). Thimerosal had strong microbicidal activity against Gram-positive bacteria, Gram-negative bacteria, yeast and fungi at 25℃ and 4℃. 2-PE also had microbicidal activity against these microorganisms, only had microbistatic activity against fungi at 4℃. Neither 2-PE nor Thimerosal affected the potency or toxicity of the DPT vaccine. These data suggest that 2-PE has weaker antimicrobial activity than Thimerosal against yeast and fungi in DPT vaccine at low temperatures.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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Nagai Masaaki
第一薬科大学 免疫薬品
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Nagai Masaaki
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute
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Sato Takaaki
Division Of Surgery Tochigi Cancer Center Hospital
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WATANABE Mineo
Department of Microbiology and Biologics, Daiichi College of Pharmaceutical Sciences
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Nagai M
Division Of Quality Control Research Center For Biologicals The Kitasato Institute
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Oishi Mitsuo
Division Of Bacterial Vaccines
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HASHIMOTO Hiroshi
Division of Rheumatology, Department of Internal Medicine, Juntendo University School of Medicine
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Komatsu Eiji
Division of Bacterial Vaccines, Research Center for Biologicals, The Kitasato Institute
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Yamazaki Hiroyuki
Division of Bacterial Vaccines
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Abe Katsuyo
Division of Bacterial Vaccines
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Iyama Shigeharu
Division of Bacterial Vaccines
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Yoshino Chiharu
Division of Quality Control, Research Center for Biologicals, The Kitasato Institute
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Watanabe Mineo
Laboratory of Pertussis, Department of Microbiology and Biologics, Daiichi College of Pharmaceutical
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Sato Takaaki
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute
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Watanabe M
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute:(present Addre
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Watanabe Mineo
Laboratory Of Bacterial Infection Kitasato Institute For Life Sciences Kitasato University
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Hashimoto Hiroshi
Division Of Cardiology Jich Medical School
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Hashimoto Hiroshi
Department Of Adult Disease Jr Tokyo General Hospital
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Hashimoto H
Division Of Quality Control Research Center For Biologicals The Kitasato Institute
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Komatsu Eiji
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute
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Yoshino Chiharu
Division Of Quality Control Research Center For Biologicals The Kitasato Institute
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