Failure of Smooth Muscle Cells Treated with Collagenase to Respond to Bordetella Heat-Labile Toxin
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概要
- 論文の詳細を見る
HLT, Bordetella heat-labile toxin, caused a release of radioactivity from cultured smooth muscle cells (SMC) previously labeled with [^<14>C]arachidonic acid, and from membrane preparations from the labeled SMC. HLT, however, failed to induced release from primary SMC prepared by treatment with an enzyme solution containing collagenase and elastase. When cultured SMC were treated with the enzyme solution, their susceptibility to HLT was reduced more significantly than that of untreated cells. SMC also lost their susceptibility, after treatment with collagenase alone, but not with elastase, in a dose-dependent manner. These data suggest that collagen on the SMC surface might play an important role in HLT activity.
- 社団法人日本薬学会の論文
- 1996-11-15
著者
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NAGAI Masaaki
Department of Earth and Space Science, Graduate School of Science, Osaka University
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Nagai Masaaki
第一薬科大学 免疫薬品
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Nagai M
Kitasato Inst. Saitama Jpn
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Nagai Masaaki
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute
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WATANABE Mineo
Department of Microbiology and Biologics, Daiichi College of Pharmaceutical Sciences
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ENDOH Masahiko
Department of Microbiology and Biologics, Daiichi College of Pharmaceutical Sciences
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DANBARA Hirofumi
Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University
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Nagai M
Division Of Quality Control Research Center For Biologicals The Kitasato Institute
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Watanabe M
Department Of Public Health Niigata College Of Medical Technology
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Watanabe M
Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute:(present Addre
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Watanabe Mineo
Department Of Microbiology And Biologics Daiichi College Of Pharmaceutical Sciences
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Endoh Masahiko
Department Of Microbiology And Biologics Daiichi College Of Pharmaceutical Sciences
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Danbara Hirofumi
Department Of Microbiology School Of Pharmaceutical Science Kitasato University
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NAGAI Masaaki
Department of Earth & Space Science, Osaka University
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