Effect of Acellular Pertussis Vaccine Against Various Strains of Bordetella Pertussis in a Murine Model of Respiratory Infection

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概要

• 論文の詳細を見る

• The protective effects of an acellular pertussis vaccine were investigated in a murine model of respiratory infection (aerosol challenge model) with various strains of Bordetella pertussis (B. pertussis) as challengers. There were no significant differences in terms of the time course of increases in numbers of bacterial cells in mouse lungs after aerosol challenge among the tested phase I strains. The vaccine had a strong protective effect against of B. pertussis strain Tohama the phase I strain used for production of the vaccine, however was less effective against other clinical isolates of pertussis. Our data suggest that a novel vaccine(s) should be developed from the strains derived from current clinical isolates to eliminate the incidence of pertussis.

• 公益社団法人日本薬学会の論文
• 2002-12-01

著者

• Nagai Masaaki

  第一薬科大学 免疫薬品

• Nagai Masaaki

  Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute

• WATANABE Mineo

  Department of Microbiology and Biologics, Daiichi College of Pharmaceutical Sciences

• Nagai M

  Division Of Quality Control Research Center For Biologicals The Kitasato Institute

• Watanabe M

  Division Of Bacterial Vaccines Research Center For Biologicals The Kitasato Institute:(present Addre

• Watanabe Mineo

  Department Of Microbiology And Biologics Daiichi College Of Pharmaceutical Sciences

関連論文

• Comparison of Characterization among Bordetella Calmodulin-Like Protein, Bovine Brain Calmodulin and Escherichia coli Acyl-Carrier Protein
• Inhibitory Effect of Acyl-CoA and Acyl-Carnitine Compounds on the Ischemia-Inducing Activity of Bordetella Heat-Labile Toxin in Guinea Pig Skin
• Failure of Smooth Muscle Cells Treated with Collagenase to Respond to Bordetella Heat-Labile Toxin
• Production of Antibody against Calmodulin Which Is a Protein with Poor Antigenicity
• Differing Protective Effects of Acellular Pertussis Vaccines in Neonatal and Young Mice in a Murine Model of Respiratory Infection
• Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine
• Effect of Acellular Pertussis Vaccine Against Various Strains of Bordetella Pertussis in a Murine Model of Respiratory Infection

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