Oral Administration of Heat-Killed Lactobacillus plantarum Strain b240 Protected Mice against Salmonella enterica Serovar Typhimurium
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to investigate the effects of heat-killed Lactobacillus plantarum strain b240 (b240) on systemic infection by Salmonella enterica serovar Typhimurium (S. Typhimurium) and to determine the mechanism by which b240 protects against infection. Mice were administered either b240 or saline orally for 3 weeks, and then inoculated with S. Typhimurium. The mice treated with b240 were significantly protected against S. Typhimurium as compared to those fed saline. Moreover, translocation of S. Typhimurium into each organ tested in the mice that received b240 tended to be less than in the control mice. An important mechanism of protection against infection was demonstrated by the ability of b240 to inhibit both binding by and invasion of S. Typhimurium into cells. These results indicate that nonviable lactic acid bacteria also play important roles in preventing infection by enteric pathogens.
- 2010-07-23
著者
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DANBARA Hirofumi
Department of Microbiology, School of Pharmaceutical Sciences, Kitasato University
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Matsumoto Tetsuya
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Matsumoto Tetsuya
Department Of Microbiology Tokyo Medical University
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Ishikawa Hiroki
Department Of Infectious Diseases Tokai University School Of Medicine
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Okada Nobuhiko
Department Of Anatomy Hiroshima University School Of Dentistry
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Maeda Yasuyuki
Department Of Biosciences Teikyo University Of Science And Technology
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Ishikawa Hiroki
Department Of Microbiology Tokyo Medical University
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Okada Nobuhiko
Department Of Microbiology School Of Pharmaceutical Science Kitasato University
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Toba Masamichi
Otsu Nutraceuticals Research Institute Otsuka Pharmaceutical Co. Ltd.
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Shirai Toshiaki
Department Of Microbiology Tokyo Medical University
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Kurihara Tatsuya
Department Of Microbiology Tokyo Medical University
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KUTSUKAKE Etsuko
Department of Microbiology, Tokyo Medical University
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FUKUI Toshie
Department of Microbiology, Tokyo Medical University
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SATO Ikutaro
Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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KOHDA Noriyuki
Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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Danbara Hirofumi
Department Of Microbiology School Of Pharmaceutical Science Kitasato University
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Matsumoto Tetsuya
Department Of Cardiovascular And Respiratory Medicine
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Sato Ikutaro
Otsu Nutraceuticals Research Institute Otsuka Pharmaceutical Co. Ltd.
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Fukui Toshie
Department Of Microbiology Tokyo Medical University
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Kohda Noriyuki
Otsu Nutraceuticals Research Institute Otsuka Pharmaceutical Co. Ltd.
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Kutsukake Etsuko
Department Of Microbiology Tokyo Medical University
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Kohda Noriyuki
Otsu Nutraceuticals Research Institute Nutraceuticals Division Otsuka Pharmaceutical Co. Ltd.
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Ishikawa Hiroki
Department of Anatomy, Showa University School of Medicine
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Shirai Toshiaki
Department of Chemistry, Faculty of Science, Science University of Tokyo
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