Experimental Study of the Mechanism of Seizure Induction: Changes in the Concentrations of Excitatory Amino Acids in the Epileptic Focus of the Cat Amygdaloid Kindling Model
スポンサーリンク
概要
- 論文の詳細を見る
L-glutamate (Glu) and L-aspartate (Asp) are two major excitatory amino acids that may be involved in seizure susceptibility and seizure induction. The concentrations of Glu and Asp were measured by microdialysis in the epileptic focus in a cat amygdaloid kindling model. Sequential changes in Glu and Asp (before, during, and after seizure) were measured in the partial seizure (S4) and generalized seizure (S6) groups. By stimulation at and 50μA below the partial seizure-triggering threshold in the S4 group and the generalized seizure-triggering threshold in the S6 group, Glu was released from the epileptic focus in the S4 group, and both Glu and Asp were released in the S6 group after seizure and stimulation (below threshold), and the amount of Glu and/or Asp release determined seizure induction. Excitatory amino acids may be the trigger of seizure induction in the cat amygdaloid kindling model.
- 日本脳神経外科学会の論文
- 1994-07-15
著者
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OHNISHI Hideyuki
Department of Neurosurgery, Osaka Neurological Institute
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NAKASE Hiroyuki
Department of Neurosurgery, Osaka Neurological Institute
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Ohnishi Hideyuki
Department Of Neurosurgery Ohnishi Neurosurgical Hospital
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SAKAKI Toshisuke
Department of Neurosurgery, Nara Medical University
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TADA Takaoki
Department of Neurosurgery, National Nara Hospital
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HASHIMOTO Hiroshi
Department of Neurosurgery, Nara Medical University
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KUROKAWA Shinichiro
Department of Neurosurgery, Nara Medical University
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HIRABAYASHI Hidehiro
Department of Neurosurgery, Nara Medical University
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HOSHIDA Tohru
Department of Neurosurgery, Nara Medical University
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川口 正一郎
奈良県立奈良病院救命救急センター
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HOSHIDA Toru
Department of Neurosurgery Nara Medical University
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Ohnishi Hideyuki
Department Of Neurological Surgery Kitano Hospital
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Nakase Hiroyuki
Department Of Neurosurgery Nara Medical University
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Nakase Hiroyuki
Department Of Neurosurgery Nara Medical University:department Of Neurosurgery Osaka Neurological Ins
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SAKAI Toshisuke
Department of Neurosurgery, Nara Medical University
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Hoshida Tohru
Department Of Neurosurgery Nara Medical University
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Hirabayashi Hidehiro
Department Of Neurosurgery Nara Medical University
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Sakaki Toshisuke
Department Of Neurological Surgery Kitano Hospital
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Hashimoto Hiroyuki
Department Of Neurosurgery Nara Medical University:m.d. Department Of Neurosurgery Okanami General H
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Hashimoto Hiroshi
Department Of Adult Disease Jr Tokyo General Hospital
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Hashimoto Hiroshi
Department Of Neurosurgery Nara Medical University
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Tada Takaoki
Department Of Neurosurgery National Nara Hospital
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Tada Takaoki
Department Of Neurosurgery Nara Medical University
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Kurokawa Shinichiro
Department Of Neurosurgery Ishinkai Yao General Hospital
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Nanase Hiroyuki
Department Of Neurosurgery Nara Medical University
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Nakase Hiroyuki
Department Of Life System Institute Of Technology And Science Graduate School The University Of Toku
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Sakaki Toshisuke
Department Of Anesthesiology Nara Medical University
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NAKASE Hiroyuki
Department of Neurosurgery, Nara Medical University
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