The Long-Term Prognosis of Lupus Nephritis Patients Treated with Intravenous Cyclophosphamide
スポンサーリンク
概要
- 論文の詳細を見る
Objective Patients with lupus nephritis receiving intravenous cyclophosphamide (IVCY) therapy were divided into groups according to their clinical course, and the long-term prognosis was evaluated. Patients and Methods A total of 67 patients with lupus nephritis were enrolled and divided as follow into the following groups: Group A: patients with fresh nephritis, Group B: patients with relapse nephritis, Group C: patients with nephritis as a transition of the main clinical manifestation. IVCY (500 mg or 750 mg) was administered every month, and continued for two to more than six months. Results The rate of remission was 78%; group A revealed a significantly higher rate of remission as compared with the other groups. Although long-term remission was revealed in most patients, some patients in Group B demonstrated a decreased rate of remission. Concerning the total dose administered, there was no relation to prognosis; a high dose was not required, especially for patients in Group A. On the other hand, the combination of steroid pulse therapy with IVCY revealed a moderate relation to the increased rate of remission in Group A. However, this combination therapy was not related to the maintenance of remission. There was no adverse effect at late onset. Conclusion The long-term prognosis of IVCY differed according to the patient's clinical course, and the result differed from those reported in other countries. Therefore, we should consider the clinical course and race specificity for the Japanese subject.
著者
-
Morimoto Shinji
Department of Cardiology, Komatsushima Red Cross Hospital
-
Nozawa Kazuhisa
Department Of Internal Medicine And Rheumatology School Of Medicine Juntendo University
-
Amano Hirofumi
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
-
Tokano Yoshiaki
Department Of Internal Medicine And Rheumatology Juntendo University School Of Medicine
-
Hashimoto Hiroshi
Department Of Adult Disease Jr Tokyo General Hospital
-
Isonuma Hiroshi
Department Of General Medicine Juntendo University School Of Medicine
-
Takasaki Yoshinari
Department of Internal Medicine and Rheumatology
-
Isonuma Hiroshi
Department of General Medicine, Juntendo University, School of Medicine
-
Matsuyama Naomi
Department of General Medicine, Juntendo University, School of Medicine
-
Nozawa Kazuhisa
Department of Rheumatology and Internal Medicine, Juntendo University, School of Medicine
-
Tokano Yoshiaki
Department of Internal Medicine and Rheumatology
-
Morimoto Shinji
Department of Rheumatology and Internal Medicine, Juntendo University, School of Medicine
-
Takasaki Yoshinari
Department of Internal Medicine
関連論文
- Experimental Study of the Mechanism of Seizure Induction: Changes in the Concentrations of Excitatory Amino Acids in the Epileptic Focus of the Cat Amygdaloid Kindling Model
- Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
- -8- INDICATIONS FOR EMERGENCY PTCA : STUDY FROM THE OUTCOME OF PATIENTS WITH FIRST AMI : PTCA : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Does long-term medication with a proton pump inhibitor induce a tolerance to H_2 receptor antagonist?
- Successful Resection of Dermatomyositis Associated with Thymic Carcinoma : Report of a Case
- Activated peripheral blood mononuclear cells detected in lupus patients using cDNA coding for proliferating cell nuclear antigen
- Crystallographic Studies on a Family B DNA Polymerase from Hyperthermophilic Archaeon Pyrococcus kodakaraensis Strain KOD1^1
- Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization
- Expression of estrogen receptors α and β in soft tissue sarcomas : Immunohistochemical and molecular analysis
- Inflammatory myofibroblastic tumor with predominant anaplastic lymphoma kinase-positive cells lacking a myofibroblastic phenotype
- Intranasal pericytic tumors (glomus tumor and sinonasal hemangiopericytoma-like tumor) : Report of two cases with review of the literature
- Trafficking of QD-Conjugated MPO-ANCA in Murine Systemic Vasculitis and Glomerulonephritis Model Mice
- Chylomicron Remnants Stimulate Release of Interleukin-1β by THP-1 Cells
- Change of Lesion Characterization after Intervention for Chronic Total Occlusions with IVUS(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Intravenous Administration of Nicorandil on Preventing Slow-Flow Phenomenon during Percutaneous Coronary Intervention in Patients with Stable Angina Pectoris
- Effects of Renin-Angiotensin System in Production of Plasminogen Activator Inhibitor Type1 by Cultured Endothelial Cells in Response to Chylomicron Remnants
- Rapid Detection of Occlusion of LAD in the Acute Coronary Syndromes with 2nd Harmonic Small-Size Transducer
- Changes of Plasma 8-Isoprostaglandin F2 α (8-ISO), 8-Hydroxy-2'-Deoxyguanosine(8-OHdG), and Malondialdehyde -Modified- LDL(MDA-LDL) After Percutaneous Coronary Intervention for Acute Myocardial Infarction
- The characteristics of intracoronary thrombus by Rescue thrombectomy
- Marked reduction in bispectral index with severe bradycardia without hypotension in a diabetic patient undergoing ophthalmic surgery
- Time-consumption risk of real-time ultrasound-guided internal jugular vein cannulation in pediatric patients : comparison with two conventional techniques
- Analysis of Risk Epitopes of Anti-Neutrophil Antibody MPO-ANCA in Vasculitis in Japanese Population
- Manual and digitizer measurements of amygdalohippocampal volume : Reliability in comparison to computer-based measurement
- Recent Clinico-epidemiological Manifestations of Primary Vasculitides
- Comparative study on novel endoluminal ultrasonography and conventional transurethral ultrasonography in staging of bladder cancer
- Reversal of acquired cisplatin resistance by modulation of metallothionein in transplanted murine tumors
- Immunohistochemical expression of P-glycoprotein in the rat urinary bladder and the effect of verapamil on intravesical chemotherapy
- Roles of p53 and MDM2 in tumor proliferation and determination of the prognosis of transitional cell carcinoma of the renal pelvis and ureter
- Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine
- Autoimmune hepatitis in primary Sjogren's syndrome : Pathological study of the livers and labial salivary glands in 17 patients with primary Sjogren's syndrome
- Effects of High Concentration of Salts on the Esterase Activity and Structure of a Kiwifruit Peptidase, Actinidain
- Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population
- Successful treatment of severe Reiter's Syndrome with etretinate
- Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma : Report of three cases
- Molecular genetic analyses of human NKG2C (KLRC2) gene deletion
- Fetal Cavernous Angioma : Case Report
- Intraneural Monophasic Synovial Sarcoma : A Case Report
- Primary leiomyosarcoma of the vertebra : Case report and review of the literature
- Myoepithelioma of soft tissue
- Glyceraldehyde 3-phosphate dehydrogenase is a novel autoantigen leading autoimmune responses to proliferating cell nuclear antigen multiprotein complexes in lupus patients
- Expression and function of fibronectin binding integrins on rat mast cells
- Exposure to a high total dosage of glucocorticoids produces non-alcoholic steatohepatits
- Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population
- Multicenter cooperative study of HLA class II alleles in Japanese patients with systemic lupus erythematosus
- Decrease in CD4^+CD25^+ and CD8^+CD28^+ T cells in interstitial pneumonitis associated with rheumatic disease
- Reactive arthritis after pharyngeal infection: report of two siblings
- Improvement of rapidly progressive lupus nephritis associated MPO-ANCA with tacrolimus
- Long-term prognosis in lupus nephritis: relation to the renal biopsy data, therapy, and grade of remission
- Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease
- Anti-Ki antibodies recognize an epitope homologous with SV40 nuclear localization signal : clinical signifficance and reactivities in various immunoassays
- Autoreactive T-cell responses to myeloperoxidase in patients with antineutrophil cytoplasmic antibody-associated vasculitis and in healthy individuals
- Hydrodynamic evaluation of axillary artery perfusion for normal and diseased aorta
- Syntheses, Structures and Solution Dynamics of Anionic 5-Coordinate Pt(II) Complexes with Halide
- Investigation of pathological and clinical features of lupus nephritis in 73 autopsied cases with systemic lupus erythematosus
- Scleredema : report of a case
- Clinicoepidemiological manifestations of RPGN and ANCA-associated vasculitides : an 11-year retrospective hospital-based study in Japan
- Current state and effectiveness of abdominal ultrasonography in complete medical screening
- Endothelial cell-binding antibodies in patients with systemic lupus erythematosus
- A case of intestinal Behcet's disease in association with HLA-B27 and HLA-B51
- Mesenchymal Tumor of the Pancreas : Report of a Case
- Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction
- Cyclosporin A therapy for interstitial pneumonitis associated with rheumatic disease
- Two cases of reactive hemophagocytic syndrome: a patient with adult-onset Still's disease and a patient with herpes zoster and autoimmune abnormalities
- An Analysis to the Subjective Evaluation Model of a Clinical Image Diagnosis with λ-Fuzzy Measures
- Application of the Sugeno Integral with λ-Fuzzy Measures to Endoscopic Diagnosis
- Role of Curdlan Sulfate in the Binding of HIV-1 gp120 to CD4 Molecules and the Production of gp120-Mediated TNF-α
- A case of mixed connective tissue disease associated with macrovascular lesions in the upper and lower extremities
- DNA copy number changes in carcinoma in pleomorphic adenoma of the salivary gland : A comparative genomic hybridization study
- A Solitary Fibrous Tumor Arising in the Perioral Region
- Extraskeletal myxoid chondrosarcoma : Updated clinicopathological and molecular genetic characteristics
- Intramuscular myxoma with fibrous dysplasia : A report of two cases with a review of the literature
- A case of very-late-onset systemic lupus erythematosus
- Aberrant MAD2 expression in soft-tissue sarcoma
- Sclerosing variant of epithelioid angiomyolipoma
- Synovial sarcomas of three children in the first decade : Clinicopathological and molecular findings
- Anti-proteasome activator 28α is a novel anti-cytoplasmic antibody in patients with systemic lupus erythematosus and Sjogren's syndrome
- CD19/22 balance relates to improvement of disease activity in systemic lupus erythematosus
- Systemic lupus erythematosus and human endogenous retroviruses
- CD154 expression and mRNA stability of activated CD4-positive T cells in patients with systemic lupus erythematosus
- Pentoxifylline induces the shedding of L-selectin on polymorphonuclear cells by stimulation via adenosine receptor as well as by the inhibition of phosphodiesterase
- Sjogren syndrome associated with multiple myeloma of the lgA _k-type
- A case of aplastic anemia in a patient with systemic lupus erythematosus
- IMMUNOLOGICAL STUDY OF CHILDREN BORN TO MOTHERS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
- Transforming Growth Factor Beta 1 Gene Polymorphism in Japanese Patients with Systemic Lupus Erythematosus
- A case of inclusion body myositis with systemic sclerosis
- Analysis of autoantibodies to cell cycle-assosiated antigens
- Cyclosporine treatment of advanced interstitial pneumonitis associated with systemic sclerosis
- Intercostal venous hemangioma presenting as a chest wall tumor
- Biphagic pulmonary blastoma with a lesion of yolk sac tumor
- Angiomyofibroblastoma of the vulva : A clinicopathologic study of seven cases
- Possible involvement of bone morphogenetic protein 2 in heterotopic ossification in metastatic lesion from urothelial carcinoma of bladder
- Relation between the levels of soluble CD4, CD8 and CD23 molecules in sera and clinical manifestations and laboratory data in patients with systemic lupus erythematosus
- A case of incidentally detected IgG4-related sclerosing disease involving inflammatory abdominal aortic aneurysm and autoimmune pancreatitis
- Alteration of Intercellular Communication in a Human Urothelial Carcinoma Cell-Line by Tumor-Promoting Agents
- Comparison of the Amino Acid Sequence and Phylogenetic Analysis of the Peplomer, Integral Membrane and Nucleocapsid Proteins of Feline, Canine and Porcine Coronaviruses
- Central nervous system involvements of patients with systemic lupus erythematosus
- Enrichment and Characterization of a Trichloroethene-Dechlorinating Consortium Containing Multiple "Dehalococcoides" Strains
- The Long-Term Prognosis of Lupus Nephritis Patients Treated with Intravenous Cyclophosphamide
- Follow Up Study on the Changes in the Clinical Features and Prognosis of Japanese Patients with Systemic Lupus Erythematosus During the Past 3 to 4 Decades
- Two Cases of Refractory Wegeners Granulomatosis Successfully Treated with Rituximab