Successful Treatment of Primary Sjögrens Syndrome with Chronic Natural Killer Lymphocytosis by High-Dose Prednisolone and Indomethacin Farnesil

スポンサーリンク

概要

• 論文の詳細を見る

• We report a patient with Sjögrens syndrome and chronic natural killer lymphocytosis, who developed severe neutropenia, autoimmune hemolytic anemia, and immune thrombocytopenia. High-dose prednisolone therapy improved the hemolytic anemia and thrombocytopenia, but not the CD16+ CD56- NK lymphocytosis completely. Interestingly, indomethacin farnesil (a prodrug of indomethacin) was effective for myalgia and also decreased the number of CD16+ CD56- NK cells. NK lymphocytosis is rarely associated with autoimmune disease, but the combination of indomethacin and steroid therapy may have a favorable effect for such patients.

著者

• Mimori Tsuneyo

  Department Of Internal Medicine Keio University School Of Medicine

• Fujii Takao

  Department Of Applied Life Science Faculty Of Biotechnology And Life Science Sojo University

• Fujita Yoshimasa

  Department Of Hematology And Immunology Kanazawa Medical University

• Tanaka Masao

  Department Of Biology Faculty Of Science Kyushu University

• Fujita Yoshimasa

  Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University

• Takeda Naho

  Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University

• Tanaka Masao

  Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University

関連論文

• Treatment capability of an up-flow anammox column reactor using polyethylene sponge strips as biomass carrier(ENVIRONMENTAL BIOTECHNOLOGY)
• Partial nitrification treatment for high ammonium wastewater from magnesium ammonium phosphate process of methane fermentation digester liquor(ENVIRONMENTAL BIOTECHNOLOGY)
• Effect of salt concentration in anammox treatment using non woven biomass carrier(ENVIRONMENTAL BIOTECHNOLOGY)
• Quantitative analysis of hTERT mRNA levels in cells microdissected from cytological specimens
• Prevention of iatrogenic bile duct injuries in difficult laparoscopic cholecystectomies : is the naso-biliary drain the answer?
• Comparison of recovery of gastric phase III motility and gastric juice output after different types of gastrointestinal reconstruction following pylorus-preserving pancreatoduodenectomy
• Effect of prepyloric gastric transection and anastomosis on sphincter of Oddi cyclic motility in conscious dogs
• Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
• Type of gastrointestinal reconstruction affects postoperative recovery after pancreatic head resection
• Complete Extirpation of a Bronchogenic Cyst Causing Recurrent Laryngeal Nerve Palsy by Thoracoscopy : Report of a Case
• Clinical aspects of intraductal papillary mucinous neoplasm of the pancreas
• Appleby Operation for Pancreatic Body-Tail Carcinoma : Report of Three Cases
• TG-3-6 Comparative study between open and laparoscopic distal pancreatectomy(Biliary tract, Pancreas,Travel Grant)
• Live multi-station teleconferences at the First Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association via academic broadband Internet
• Significant Clinical Differences in Primary Hyperparathyroidism Between Patients with and Those Without Concomitant Thyroid Disease
• Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs
• Thyroid Evaluation in Patients with Primary Hyperparathyroidism
• A minute nonfunctioning islet cell tumor demonstrating malignant features
• Familial pancreatic cancer : report of one Japanese family
• Cystadenocarcinoma of the liver without mesenchymal stroma : possible progression from a benign cystic lesion suspected by follow-up imagings
• Protein Stone Formation in an Intrapancreatic Remnant Cyst After Resection of a Choledochal Cyst
• A vanishing pseudocyst in the remnant pancreas after pylorus-preserving pancreatoduodenectomy
• Benign Mediastinal Teratoma Complicated by Cardiac Tamponade : Report of a Case
• Mediastinal Lymph Node Metastasis of Colon Cancer: Report of a Case
• Adenoid Cystic Carcinoma of the Esophagus: Report of a Case
• Laparoscopic choledochotomy for bile duct stones
• A Nitroimidazole Derivative, PR-350, Enhances the Killing of Pancreatic Cancer Cells Exposed to High-dose Irradiation under Hypoxia
• Hemorrhagic pseudocyst and pseudocyst with pseudoaneurysm successfully treated by pancreatectomy : report of three cases
• Stricture of the Main Pancreatic Duct Due to Focal Pancreatitis Coexistent with Pancreatic Cystadenoma
• Surgical bypass versus metallic stent for unresectable pancreatic cancer
• Cyclic motility of the sphincter of Oddi
• Endoscopic retrograde cholangiopancreatography in infants and children
• Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation
• Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells
• Amelioration of experimental arthritis by a calpain-inhibitory compound : regulation of cytokine production by E-64-d in vivo and in vitro
• Cytochrome P450rm from Rhodotorula minuta Catalyzes 4-Hydroxylation of Benzoate
• Purification and Characterization of Cytochrome P450 from an Isobutene-forming Microorganism, Rhodotorula minuta
• Purification and Characterization of Cytochrome b_5 from Rhodotorula minuta
• The Stimulatory Effect of Catalase on the Formation in vitro of Ethylene by an Ethylene-Forming Enzyme Purified from Penicillium digitatum
• Classification of Ethylene-Producing Bacteria in Terms of Biosynthetic Pathways to Ethylene
• The Role of NADH : Fe(III)EDTA Oxidoreductase in Ethylene Formation from 2-Keto-4-Methylthiobutyrate
• The Relationship between Isobutene-Forming Activity and a Cytochrome P-450 in Rhodotorula minuta
• Partial nitritation treatment of underground brine waste with high ammonium and salt content(ENVIRONMENTAL BIOTECHNOLOGY)
• Another Multiheme Protein, Hydroxylamine Oxidoreductase, Abundantly Produced in an Anammox Bacterium Besides the Hydrazine-Oxidizing Enzyme(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• Characterization of anticytoplasmic antibodies in patients with systemic autoimmune diseases
• Efficacy and safety of mizoribine for the treatment of Sjogren's syndrome : a multicenter open-label clinical trial
• Enhanced Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) at the Culprit Lesion in Patients with Acute Coronary Syndromes
• Long-term Clinical Course of a Patient with Anti PL-12 Antibody Accompanied by Interstitial Pneumonia and Severe Pulmonary Hypertension
• Severe hypertention associated with multiple intrarenal microaneurysms in a patient with systemic lupus erythematosus and antiphospholipid antibodies
• Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis
• Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus
• A case of late-onset polymyositis with autoantibodies to the signal recognition particle
• Clinical Significance of Anti-CCP Antibodies in Rheumatoid Arthritis
• 生物担体としてモルトセラミックを活用したAnammox処理性能
• Incidence of Pulmonary Hypertension and Its Clinical Relevance in Patients with Interstitial Pneumonias: Comparison between Idiopathic and Collagen Vascular Disease Associated Interstitial Pneumonias
• Sensorimotor polyneuropathy as an initial clinical manifestation of sarcoidosis
• Ethylene Production from L-Methionine by Cryptococcus albidus
• Preparation of a Cell-free Ethylene-forming System from Penicillium digitatum
• A Screening System for Microbes which Produce Olefin Hydrocarbons
• Microbial Production of C2- Hydrocarbons, Ethane, Ethylene and Acetylene
• Elevated levels of oxidized low density lipoprotein (ox-LDL) relate to plaque instability in diabetic patients
• Aspirated intracoronary thrombus by Rescue^ PT catheter : histological and immunohistochemical analyses
• Strong Expression of Pro-oxidant Enzyme Myeloperoxidase in Human Coronary Unstable Plaques
• Plasma Oxidized Low Density Lipoprotein Levels Predict Stent Restenosis in Patients with Acute Myocardial Infarction Compared to Balloon Angioplasty
• Increased Plasma levels of Oxidized Low-Density Lipoprotein Relate to Coronary Artery Calcification in Patients mith Acute Myocardial Infarction
• Plasma oxidized low density lipoprotein levels in patients with coronary artery disease, gastritis with Helicobacter pylori infection, inflammatory bowel disease
• Positive correlation between oxidized low-density lipoprotein levels and the extent of coronary artery disease in patients with stable angina pectoris
• Increased Expression of Lectin-like Oxidized Low-density Lipoprotein Receptor 1(LOX-1)in Coronary Unstable Plaques Obtained by Atherectomy
• A link between high plasma oxidized low density lipoprotein (ox-LDL) levels and the severity of unstable angina pectoris
• Periodic fever and erythema nodosum associated with MDS with trisomy 8 : report of two cases and review of the literature
• Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men
• Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population
• Characterization of the Microbial Community in an Anaerobic Ammonium-Oxidizing Bioflim Cultured on a Nonwoven Biomass Carrier(ENVIRONMENTAL BIOTECHNOLOGY)
• Ku Antigen Binds to Alu Family DNA^1
• Cytochrome P450rm of RhodotorulaFunctions in the β-Ketoadipate Pathway for Dissimilation of _L-Phenylalanine
• Molecular Characterization of a Rhodotorula-lytic Enzyme from Paecilomyces lilacinus Having β-1, 3-Mannanase Activity
• Aseptic meningitis in mixed connective tissue disease : cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases
• High-rate nitrogen removal from anaerobic digester liquor using an up-flow anammox reactor with polyethylene sponge as a biomass carrier(ENVIRONMENTAL BIOTECHNOLOGY)
• Reject water treatment by improvement of whole cell anammox entrapment using polyvinyl alcohol/alginate gel
• High-rate Partial Nitrification Treatment of Reject Water as Pretreatment for Anammox
• The Role of L-Phenylalanine in the Peoduction of Isobutene by Rhodotorula minuta
• High-dose methotrexate with R-CHOP therapy for the treatment of patients with primary central nervous system lymphoma
• The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8mg/week in patients with rheumatoid arthritis
• Polymyositis associated with autoimmune hepatitis, primary biliary cirrhosis, and autoimmune thrombocytopenic purpura
• Successful Treatment of Primary Sjögrens Syndrome with Chronic Natural Killer Lymphocytosis by High-Dose Prednisolone and Indomethacin Farnesil
• Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011
• A novel clinical entity, IgG4-related disease (IgG4RD) : general concept and details
• A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations
• Antisynthetase Syndrome Associated with Sarcoidosis
• PVAゲルビーズを微生物担体として活用するアナモックスプロセスの処理能力と微生物菌叢
• Serum IgG levels demonstrate seasonal change in connective tissue diseases : a large-scale, 4-year analysis in Japanese
• The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucyl-tRNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/Dermatomyositis
• Therapeutic response of patients with adult Still's disease to biologic agents : multicenter results in Japan
• NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA
• Clinical Features and Treatment of Multicentric Castleman's Disease : A Retrospective Study of 21 Japanese Patients at a Single Institute
• Leukoencephalopathy with Cognitive Impairment following Tocilizumab for the Treatment of Rheumatoid Arthritis (RA)
• Production of a Gaseous Saturated-hydrocarbon Mixture by Rhizopus japonicus under Aerobic Conditions
• Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis
• Clinical Features and Treatment of Multicentric Castleman's Disease : A Retrospective Study of 21 Japanese Patients at a Single Institute
• Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate : a randomized, double-blind, placebo-controlled trial

もっと見る 閉じる

スポンサーリンク