Leukoencephalopathy with Cognitive Impairment following Tocilizumab for the Treatment of Rheumatoid Arthritis (RA)
スポンサーリンク
概要
- 論文の詳細を見る
The biological agent tocilizumab, is a humanized, anti-human interleukin-6 receptor antibody. A 72-year-old woman developed cognitive impairment during the Phase III clinical trial of tocilizumab for the treatment of rheumatoid arthritis. MRI demonstrated hyperintense dissemination throughout the white matter on T2WI. An initial diagnosis of possible progressive multifocal leukoencephalopathy was made, but the PCR for JC virus DNA was negative in the CSF. The leukoencephalopathy might have been caused by a mechanism related to tocilizumab itself. It is strongly recommended to perform MRI if a patient develops any cognitive impairment during tocilizumab therapy.
- 社団法人 日本内科学会の論文
著者
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Kobayashi Katsuya
Department Of Cardiology Miki City Hospital
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Miki Yukio
Department Of Diagnostic Imaging And Nuclear Medicine Graduate School Of Medicine Kyoto University
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Kawamata Jun
Department Of Chemistry And Earth Sciences Faculty Of Science Yamaguchi University
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Mimori Tsuneyo
Department Of Internal Medicine Keio University School Of Medicine
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Tomimoto Hidekazu
Department Of Neurology Faculty Of Medicine Kyoto University
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Usui Takashi
Department Of Cardiology Fujisawa City Hospital
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Okamoto Yoko
Department Of Ophthalmology Nagoya University School Of Medicine
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Takahashi Ryosuke
Department Of Natural History Sciences Graduate School Of Science Hokkaido University
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Usui Takashi
Department of Rheumatology and Clinical Immunology, Kyoto University Hospital
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Ihara Masafumi
Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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Mimori Tsuneyo
Department of Rheumatology and Clinical Immunology, Kyoto University Hospital
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Tomimoto Hidekazu
Department of Neurology, Mie University Hospital
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Inoue Haruhisa
Department of Neurology, Kyoto University Hospital
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Kawamata Jun
Department of Neurology, Kyoto University Hospital
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