CLINICAL STUDIES ON APEXCARDIOGRAM PART III. EFFECTS OF LOW OXYGEN INHALATION AND VARIOUS PHARMACOLOGICAL TESTS ON THE APEX BEAT IN CARDIAC PATIENTS

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Apexcardiogram after low oxygen and several drugs were examined to develop the diagnostic significance of it. ACG was recorded before and after low oxygen inhalation, administration of digitalis, isoproterenol, propranolol, and amyl nitrite, in patients with ischemic heart diseases, valvular diseases, and noncardiac patients. In-creased A Wave Ratio (AWR), shortened isometric contraction time (ICT) and relaxation time (IRT) were observed after exercise, administration of isoproterenol and amyl nitrite. Shorter ICT and longer IRT were detected after digitalis. However, digitalis invariably prolonged Filling Time in ACG. Various changes of AWR, prolonged ICT and IRT were induced by propranolol. Both in valvular and coronary heart diseases, A wave was significantly increased by hypoxia, though it was stable in noncardiac patients. Prominent A wave was observed at the anginal episode by hypoxic condition in coronary heart disease. Though positive ECG and ACG findings were observed in patients with old myocardial infarction or typical angina pectoris by hypoxia, negative ECG and positive ACG findings were obtained in approximately two thirds of the patients to show slight ST, T changes in ECG at rest. It was revealed as conclusion in this study, that ACG with exercise, hypoxic and pharmacological tests could give the useful pathophysiological informations about the cardiovascular system.
社団法人日本循環器学会の論文
1971-10-20