放射線類似化学物質4NQOによる染色体異常の誘発機構〔英文〕

概要

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1. Chromosome aberrations induced by a radiomimetic chemical, 4-nitroquinoline 1-oxide, in Yoshida sarcoma cells were of chromatid type.2. The distribution of chromatid intrachanges (breakages) among cells was nonrandom. Frequency of intrachanges in each chromosome group was not proportional to the length of metaphase chromosomes.3. The distribution of chromatid interchanges (translocations) among cells was also nonrandom.4. Frequencies of both intra- and interchanges increased proportionally to the dose 8hr. after treatment. However, the frequency of interchanges observed 24hr. after treatment showed no proportional to the dose.5. The aberrations were largely localized in the neighbourhood of the secondary constrictions. Possible interpretations for their origin as well as for their location in those regions were presented.
日本遺伝学会の論文