Structural Changes of Quinoxaline Derivatives, with Special Reference to 2-(2, 3 -Dihydroxypropyl)-3-hydroxymethylquinoxaline in Alakaline and Acidic Solutions
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概要
- 論文の詳細を見る
Conversion products of 2-(2, 3-dihydroxypropyl)-3-hydroxymethylquinoxaline under alkaline and acidic refluxed conditions were characterized using GLC, GC-MS, HPLC, and NMR measurements. In an alkaline solution (pH 10, carbonate buffer), 2-(2, 3-dihydroxypropyl)-3-methylquinoxaline (GA-I) and 2-(2, 3dihydroxypropyl)quinoxaline were produced in yields of 16% and 19%, respectively, whereas in an acidic solution (MeOH-AcOH-H2O=4:5:2), a large amount (65%) of 3, 4-dihydro-1H-pyrano[3, 4-b]quinoxalin-3-yl methanol and a small amount (5%) of GA-I were obtained. These results suggest that the C-C linkage of the side chain in the quinoxaline readily splits in alkaline solutions, whereas in acidic solutions no such splitting can be observed, but condensation or dehydration occurs between hydroxyl groups of the side chains, or the hydroxymethyl group is reduced to a methyl group.
- 社団法人 日本農芸化学会の論文
著者
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HAYASHI Hideo
Deparment of Applied Biological Chemistry, College of Agriculture, Osaka Prefecture University
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MORITA Naofumi
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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TAKAGI Masanosuke
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Takagi Masanosuke
Department Of Agricultural Chemistry
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INOUE Keiichi
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Takagi Masanosuke
Department o f Agricultural Chemistry, College o f Agriculture, University
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