SUBACUTE TOXICITY OF (-)15-DEOXYSPERGUALIN IN BALB/c MICE. II. HISTOPATHOLOGICAL STUDY

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概要

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• Following the preceding report on hematological aspects in subacute toxicity of (-)15-deoxyspergualin (DSP), the present report dealt with the histopathological changes produced by DSP, 0.5-5.0 mg/kg, given to BALB/c mice for three months. At sacrifice, various internal organs such as heart, lungs, liver, spleen and kidneys, were taken, and their wet weights immediately measured. HE- or PAS-stained sections were histopathologically studied under light microscope. Additionally, frozen sections of the spleen were prepared to evaluate the effect of DSP on the lymphocyte surface markers like thy 1 and B220 by avidin-biotin complex (ABC) technique. Although the mean weights of lungs, liver, spleen and kidneys in the 0.5 mg- and 2.5 mg-DSP groups were not significantly different from those in the control animals, the weights of the heart, lungs, liver and spleen in the 5 mg-DSP group were significantly lower. Histopathological studies by light microscopy revealed no abnormalities in the heart, lungs, liver or kidneys taken from the mice given 0.5-5.0 mg/kg DSP. In contrast, significant changes were observed in the spleen and bone marrow of the 5.0 mg group of mice. Likewise, in the intestine of the 0.5-5.0 mg groups dose-dependent lesions, such as degeneration or disappearance of the mucosal epithelium, infiltration by inflammatory cells, and pseudo-membrane formation, was observed. By ABC technique, preferential decrease of B cells was seen in the splenic corpuscles of the DSP-treated mice. Histopathological changes due to DSP predominantly seen in the lymphoid and/or hematopoietic organs may be directly related to the immunosuppressive potency inherent to this drug. On the other hand, direct toxicolgical effect of DSP up to 5.0 mg/kg may not necessarily be of major significance, considering the normal histology in the heart, lungs, liver or kidneys.

• 日本トキシコロジー学会の論文
• 1989-11-25

著者

• Inoue Keiichi

  Departments Of Medicine Kitasato University School Of Medicine

• Inoue K

  National Grassland Research Institute Nishinasuno

• Okubo Michihito

  Department of Sano-Kosei Genaral Hospital, Kitasato University School of Medicine

• Kamata Kouju

  Department of Internal Medicine, Kitasato University School of Medicine

• Zhang H

  Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn

• Inoue Keiichi

  Department Of Frontier Materials Nagoya Institute Of Technology

• Masaki Yoshihiko

  Experimental Animals Kitasato University School Of Medicine

• Kamata Kouju

  Departments Of Medicine Kitasato University School Of Medicine

• Kamata Kouju

  Department Of Internal Medicine Kitasato University School Of Medicine

• Okubo M

  Fuji Reserch Laboratories Pharmaceutical Division Kowa Campany Ltd.

• ZHANG Huiming

  Pathology, Kitasato University School of Medicine

• HARA Rieko

  Clinical Pathology, Kitasato University School of Medicine

• Okubo Michihito

  Department Of Internal Medicine & Department Of Otorhinolaryngology Keio University School Of Me

• Zhang Huiming

  Pathology Kitasato University School Of Medicine

• Hara Rieko

  Clinical Pathology Kitasato University School Of Medicine

• Kamata Kouju

  Department Of Internal Medicine Kitasato University Graduate School Of Medical Sciences

• Inoue Keiichi

  Department Of Chemsitry Kyoto University

• Kamata Kouju

  Department Of Cellular And Molecular Physiology Kitasato University Graduate School Of Medical Sciences

• INOUE Keiichi

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

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